TABLE 4

Factors associated with discontinuing treatment due to adverse events

Stopped due to adverse eventsUnivariableMultivariable
NoYes#OR (95% CI)p-valueaOR (95% CI)p-value
Total25 6262105 (7.6)
Period
 1993–19965198332 (6.0)1.01.0
 1997–20005593506 (8.3)1.4 (1.2–1.6)<0.0011.4 (1.2–1.4)<0.001
 2001–20045419554 (9.3)1.6 (1.4–1.8)<0.0011.6 (1.3–1.8)<0.001
 2005–20084735461 (8.9)1.5 (1.3–1.8)<0.0011.5 (1.3–1.8)<0.001
 2009–20134681252 (5.1)0.84 (0.71–1.00)0.051.1 (0.90–1.4)0.29
Age group years
 0–14304238 (1.2)1.01.0
 15–248127419 (4.9)4.1 (3.0–5.8)<0.0013.7 (2.6–5.2)<0.001
 25–346359526 (7.6)6.6 (4.7–9.2)<0.0016.6 (4.7–9.2)<0.001
 35–444508548 (10.8)9.7 (7.0–13.5)<0.0019.9 (7.1–13.8)<0.001
 45–542649442 (14.3)13.4 (9.6–18.7)<0.00114.0 (10.0–19.6)<0.001
 55–64750110 (12.8)11.7 (8.0–17.1)<0.00115.5 (10.5–22.7)<0.001
 ≥6519122 (10.3)9.0 (5.2–15.5)<0.00114.4 (8.1–25.6)<0.001
Sex
 Male12 781809 (6.0)1.01.0
 Female12 8241296 (9.2)1.6 (1.5–1.8)<0.0011.7 (1.6–1.9)<0.001
Origin
 Foreign born4297176 (3.9)1.01.0
 Dutch born21 1361918 (8.3)2.2 (1.9–2.6)<0.0011.8 (1.5–2.1)<0.001
 Unknown19311 (5.4)1.4 (0.75–2.6)0.291.3 (0.67–2.4)0.46
Residence
 Urban6025349 (5.5)1.01.0
 Rural19 6011756 (8.2)1.5 (1.4–1.7)<0.0011.3 (1.2–1.5)<0.001
Target group
 TB contact16 1921368 (7.8)1.01.0
 Immunosuppression66951 (7.1)0.90 (0.67–1.2)0.460.57 (0.41–0.79)<0.001
 Pre-exposure examination4469362 (7.5)0.96 (0.85–1.1)0.491.0 (0.90–1.2)0.80
 Professional at risk35628 (7.3)0.93 (0.63–1.4)0.720.87 (0.58–1.3)0.48
 Traveller52527 (4.9)0.61 (0.41–0.90)0.010.75 (0.50–1.1)0.16
 Other post-exposure3309265 (7.4)0.94 (0.82–1.1)0.411.1 (0.91–1.2)0.50
 Fibrotic lesions1064 (3.6)0.45 (0.16–1.2)0.110.62 (0.22–1.7)0.36
Preventive treatment regimen
 6–9 months isoniazid20 9911850 (8.1)1.01.0
 4 months rifampicin69438 (5.2)0.62 (0.45–087)0.0050.63 (0.44–0.90)0.01
 3–4 months rifampicin/isoniazid2818122 (4.1)0.49 (0.41–0.59)<0.0010.58 (0.45–0.74)<0.001
 Other or unknown112395 (8.5)1.1 (0.89–1.4)0.330.93 (0.74–1.2)0.56
  • Data are presented as n or n (%), unless otherwise stated. OR: odds ratio; aOR: adjusted OR; TB: tuberculosis. #: percentage stopped of row total given in parentheses; : post-exposure.