TABLE 1

Major clinical characteristics of subjects at baseline

Sex male/female65/22
Age at baseline years68 (45–87)
Age at diagnosis years61 (30–83)
BMI kg·m−226.40 (16.67–38.19)
GOLD stage#
 11
 235
 332
 419
Smoking status
 Current smoker37
 Ex-smoker48
 Nonsmoker2
Smoking history pack-years50 (6–158)
Number of exacerbations
 146
 231
 39
 41
Treatment¶,+
 Antibiotics21
 Steroids8
 Antibiotics and steroids65
FEV1 L1.3±0.1
FEV1 % pred47.4±2.0
FEV1/FVC ratio46.7±1.4
CRQ score16.2±0.5
Symptom VAS total mm159.6±8.5
SGRQ score52.9±1.9
  • Data are presented as n, mean (range) or mean±sem. BMI: body mass index; GOLD: Global Initiative for Chronic Obstructive Lung Disease; FEV1: forced expiratory volume in 1s; FVC: forced vital capacity; CRQ: Chronic Respiratory Disease Questionnaire; VAS: visual analogue scale; SGRQ: St George's Respiratory Questionnaire. #: baseline visits prior to the stable visits for sputum collection; : treatments administered for exacerbations; assessments at exacerbation were prior to initiation of therapy; +: numbers represent exacerbation events, thus include subjects with more than one exacerbation.