TABLE 4

List of clinical variables significantly associated with microbial α and β diversity in group I subjects

α diversityβ diversity
Shannon's HObserved speciesFaith's phylogenetic diversityChao1Positive/negative correlationOTUGenus (L6)Phylum (L2)
Sputum CXCL8/IL-8**********Negative#****
Baseline SGRQ symptom#*********Negative
BMI***#Positive###,¶
Sputum CXCL11/ITAC#****Positive
Serum TNF-α**##Positive
Serum SAA-1#**#Positive
Serum CCL26/eotaxin3*###Negative
Serum CSF-2*###Positive##*
Serum IL-10*###Positive
Sputum MMP-8#*##Negative
Blood monocytes##**#Positive
Blood basophils##*#Positive
Serum MMP-7****#
Sputum neutrophil percentage******
Exacerbation frequency###,¶
  • OTU: operational taxonomic units; CXCL: chemokine (C-X-C motif) ligand; IL: interleukin; SGRQ: St George's Respiratory Questionnaire; BMI: body mass index; ITAC: interferon inducible T-cell α chemoattractant; TNF: tumour necrosis factor; SAA: serum amyloid A; CCL: CC-chemokine ligand; CSF: colony stimulating factor; MMP: matrix metalloproteinase. #: p≥0.05 and absent in the model; : not significantly associated with L2 β diversity, but present in its model. *: p<0.05; **: p<0.01; ***: p<0.001.