TABLE 2

Baseline characteristics in the four clusters

Cluster 1:
Pseudomonas
Cluster 2:
“Other chronic infection”
Cluster 3:
“Daily sputum”
Cluster 4:
“Dry bronchiectasis”
Overall p-value
Patients179 (100)273 (100)373 (100)307 (100)
Centre<0.0001
 Dundee, UK44 (24)128 (47)90 (24)24 (8)
 Leuven, Belgium16 (9)19 (7)66 (18)89 (29)
 Monza, Italy23 (13)24 (9)87 (23)96 (31)
 Galway, Ireland39 (22)78 (28)74 (20)89 (29)
 Athens, Greece57 (32)24 (9)56 (15)9 (3)
Demographics and comorbidities
 Age years67 (56–75)65 (56–73)67 (57–74)66 (55–74)0.52
 Male81 (45)112 (41)148 (40)109 (36)0.19
 BMI kg·m–225 (21–27)25 (22–28)25 (22–28)25 (21–28)0.47
 Smoker/ex-smoker56 (31)90 (33)165 (44)121 (39)0.005
 CCI >153 (30)101 (37)113 (30)106 (35)0.20
Disease severity
 BSI score14 (11–17)7 (5–10)6 (3–9)5 (3–7)0.0001
 FACED score4 (2–5)2 (1–3)2 (1–3)1 (0–3)<0.001
Radiological status
 Reiff score6 (4–9)4 (2–6)3 (2–6)3 (2–6)0.0001
Clinical status
 Daily cough170 (95)241 (88)322 (86)154 (50)<0.0001
 Daily sputum166 (93)204 (75)362 (97)0 (0)<0.0001
 Prior history of haemoptysis42 (24)36 (13)80 (22)43 (14)0.002
 MRC breathlessness scale3 (2–5)2 (1–3)2 (1–3)1 (1–2)0.0001
 Long-term oxygen therapy34 (19)14 (5.1)36 (9.7)0 (0)<0.0001
 Exacerbations in the previous year3 (2–4)2 (1–3)2 (1–3)2 (1–3)0.0001
 At least one hospitalisation   in the previous year109 (61)63 (23)90 (24)36 (12)<0.0001
Functional status
 FEV1 % predicted59 (46–78)71 (55–93)77 (57–95)84 (68–101)0.0001
Microbiology
 Chronic infection with Pseudomonas   aeruginosa179 (100)0 (0)0 (0)0 (0)<0.0001
 Chronic infection with other   pathogens0 (0)273 (100)0 (0)0 (0)<0.0001
Laboratory findings
 C-reactive protein mg·L−110.7 (4.0–36.0)5.0 (3.7–9.0)4.5 (2.0–7.7)3.0 (1.2–7.2)0.0001
Long-term antibiotic treatment
 Either macrolide or inhaled antibiotics120 (67)105 (39)122 (33)38 (12)<0.0001
 Macrolide97 (54)103 (38)119 (32)37 (12)<0.0001
 Inhaled antibiotics64 (36)15 (5.5)7 (1.9)2 (0.7)<0.0001
 Both macrolide and inhaled41 (23)13 (4.8)4 (1.1)1 (0.3)<0.0001
  • Data are presented as n (%) or median (interquartile range), unless otherwise stated. BMI: body mass index; CCI: Charlson Comorbidity Index; BSI: Bronchiectasis Severity Index; MRC: Medical Research Council; FEV1: forced expiratory volume in 1 s.