TABLE 1

Patient characteristics of the entire study population

Study cohort1145
Demographics and comorbidities
 Age years66 (56–74)
 Male455 (40)
 BMI kg·m–225 (22–28)
 Smoker/ex-smoker437 (38)
 CCI >1373 (33)
Aetiology of bronchiectasis
 Idiopathic373 (34)
 Post-infective290 (26)
 COPD120 (11)
 Connective tissue disease89 (8)
 Immunodeficiency56 (5)
 ABPA54 (4.9)
 Asthma35 (3.2)
 Inflammatory bowel disease24 (2.2)
 Ciliary dysfunction20 (1.8)
 Aspiration14 (1.3)
 α1-antitrypsin deficiency10 (0.9)
 Congenital5 (0.5)
 Other20 (1.8)
Disease severity
 BSI score6 (4–11)
 FACED score2 (1–3)
Radiological status
 Reiff score4 (2–6)
Clinical status
 Daily cough899 (79)
 Daily sputum744 (65)
 Prior history of haemoptysis206 (18)
 MRC breathlessness scale2 (1–3)
 Long-term oxygen therapy86 (7.5)
 Exacerbations in the previous year2 (1–3)
 At least one hospitalisation in the previous year307 (27)
Functional status
 FEV1 % predicted75 (55–95)
Microbiology
 Chronic infection with at least one pathogen#455 (40)
  Haemophilus influenzae185 (16)
  Pseudomonas aeruginosa180 (15)
  Meticillin-sensitive Staphylococcus aureus61 (5.3)
  Moraxella catarrhalis51 (4.5)
  Streptococcus pneumoniae47 (4.1)
  Enterobacteriaceae29 (2.5)
  Meticillin-resistant Staphylococcus aureus21 (1.8)
  Escherichia coli14 (1.2)
  Klebsiella pneumoniae13 (1.1)
  Nontuberculous mycobacteria8 (0.7)
  Other31 (2.7)
Laboratory findings
 C-reactive protein mg·L−16 (4–8)
Long-term antibiotic treatment
 Either macrolide or inhaled antibiotics388 (34)
 Macrolide358 (31.3)
 Inhaled antibiotic treatment90 (7.9)
 Both macrolide and inhaled antibiotics60 (5.2)
  • Data are presented as n, median (interquartile range) or n (%). BMI: body mass index; CCI: Charlson Comorbidity Index; COPD: chronic obstructive pulmonary disease; ABPA: allergic bronchopulmonary aspergillosis; BSI: Bronchiectasis Severity Index; MRC: Medical Research Council; FEV1: forced expiratory volume in 1 s. #: 150 patients had more than one pathogen as the cause of chronic infection; among those, 56 patients had Pseudomonas aeruginosa plus another bacterial species.