TABLE 1

Characteristics of healthy and asthma subjects grouped by mast cell subtype

Healthy subjectsAsthma subjectsp-value
Non-MC groupMCT/CPA3 subtypeMCT subtype
Subjects1682918
Female/male8/87/113/1610/80.195
Age years46.8±22.554.4±11.758.3±16.461.3±5.70.0558
Atopy yes/no7/94/421/812/60.236
BMI kg·m−225.79±4.1036.4±11.529.7±6.631.6±5.70.0044
Smoking ex/never5/113/515/149/90.549
Pack-years0 (0–5.93)0 (0–2.1)0.04 (0–5)0.58 (0–18)0.703
FeNO ppb11.85 (0–15.95)16.0 (10.7–21.2)33.4 (17.6–54.7)#,+17.8 (14.2–23.7)0.0059
FEV1 % predicted100.38±12.5384.63±18.6571.76±15.7674.44±22.65<0.001
FVC % predicted104.75±16.0294.0±17.5189.56±16.3488.65±16.010.0188
FEV1/FVC %79.31±7.6273.0±8.7865.07±10.0967.5±9.790.0001
ACQ score0.6 (0.35–0.71)1.4 (0.71–1.90)+0.9 (0.4–1.3)0.036
ICS use7 (87.5)19 (65.51)11 (61.11)0.399
ICS dose μg1500 (0–2000)400 (0–1000)600 (0–1600)0.190
GINA pattern intermittent/mild/  moderate/severe3/1/3/17/2/10/109/1/3/50.537
Total cell count in induced sputum ×106 mL–13.78 (2.34–5.13)3.1 (1.6–3.5)3.2 (2.3–5.9)3.4 (2.3–6.6)0.806
Viability80.7 (66.67–91.84)89.7 (72.4–93.3)74.1 (58.3–88.9)ƒ90.1 (76.5–93.3)0.0454
Neutrophils
 %28.5 (10.5–60.0)46.1 (40.1–76.5)39.8 (18.0–63.5)65.3 (43.8–78.5)#0.0181
 Count ×104 mL–157.24 (33.08–220.59)99.3 (55.1–275.2)139.2 (43.7–237.4)222.1 (89.3–545.3)0.2356
Eosinophils
 %0.25 (0–0.75)0 (0–0.1)7.3 (1.0–24.8)¶,§,##0.8 (0.3–3.3)ƒ0.0001
 Count ×104 mL–10.38 (0–2.48)0 (0–0.2)23.5 (3.9–105.3)¶,+,ƒ3.9 (0.6–14.9)0.0001
Macrophages
 %68.5 (36.75–78.5)52.4 (19.6–57.5)35.0 (22.6–57.5)#27.5 (19.0–50.5)#0.0335
 Count ×104 mL–1161.30 (46.94–294.64)80.6 (75.2–179.0)107.4 (59.1–218.7)93.2 (55.6–184.8)0.4108
  • Data are presented as n, mean±sd, median (interquartile range) or n (%), unless otherwise stated. BMI: body mass index; FeNO: exhaled nitric oxide fraction; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; ACQ: Asthma Control Questionnaire; ICS: inhaled corticosteroid; GINA: Global Initiative for Asthma. #: p<0.05, : p<0.01 compared with healthy subjects. +: p<0.05, §: p<0.01 compared with non-MC; ƒ: p<0.05, ##: p<0.01 compared with MCT.