Quantitative high-resolution computed tomography results for whole-lung fibrosis
| Cohort 1 | Cohort 2 | All | |||||||
| BL | Change from BL | BL | Change from BL | BL | Change from BL | ||||
| 24 weeks | 48 weeks | 24 weeks | 48 weeks | 24 weeks | 48 weeks | ||||
| Subjects n | 53 | 46 | 39 | 36 | 30 | 28 | 89 | 76 | 67 |
| QLF % | |||||||||
| Mean±se | 20.2±1.6 | 2.46±0.94 | 3.59±1.08 | 18.8±1.8 | 2.30±1.10 | 3.75±1.42 | 19.6±1.2 | 2.39±0.71 | 3.66±0.86 |
| Median (range) | 19.0 (2–51) | 1.0 (−10–26) | 2.0 (−6–27) | 17.0 (2–44) | 2.0 (−10–19) | 2.0 (−13–26) | 18.0 (2–51) | 1.5 (−10–26) | 2.0 (−13–27) |
| GG % | |||||||||
| Mean±se | 18.3±1.1 | −0.80±0.71 | −0.90±0.82 | 18.0±1.3 | 0.73±0.78 | 1.71±0.72 | 18.2±0.8 | −0.20±0.53 | 0.19±0.58 |
| Median (range) | 18.0 (5–42) | 0.0 (−13–8) | 0.0 (−12–12) | 17.5 (7–33) | 1.0 (−10–10) | 1.0 (−6–10) | 18.0 (5–42) | 0.0 (−13–10) | 0.0 (−12–12) |
| HC % | |||||||||
| Mean±se | 3.9±1.1 | −0.17±0.42 | −0.26±0.26 | 2.3±0.52 | 0.20±0.35 | −0.61±0.29 | 3.3±0.67 | −0.03±0.29 | −0.40±0.20 |
| Median (range) | 1.0 (0.0–37) | 0.0 (−13–7) | 0.0 (−5–5) | 1.0 (0–13) | 0.0 (−5–7) | 0.0 (−7–1) | 1.0 (0–37) | 0.0 (−13–7) | 0.0 (−7–5) |
| QILD score | |||||||||
| Mean±se | 42.4±2.5 | 1.48±1.25 | 2.44±1.61 | 39.0±2.9 | 3.23±1.69 | 4.86±1.76 | 41.0±1.9 | 2.17±1.01 | 3.45±1.19 |
| Median (range) | 44.0 (9–93) | 1.0 (−19–26) | 2.0 (−16–28) | 37.0 (11–74) | 3.5 (−16–31) | 3.5 (−22–22) | 39.0 (9–85) | 1.5 (−19–31) | 3.0 (−22–28) |
| TLC mL | |||||||||
| Mean±se | 3673±119 | −64±61 | −190±76 | 4020±168 | −129±81 | −133±91 | 3813±99 | −89±48 | −166±58 |
| Median (range) | 3513 (2421–6485) | −120 (−966–1423) | −161 (−1380–889) | 3741 (2398–6422) | −145 (−1410–875) | −142 (−1002–1467) | 3565 (2398–6485) | −135 (−1410–1423) | −158 (−1380–1467) |
All data are from observed values. BL: baseline; QLF: reticular fibrosis with architectural distortion; GG: ground glass; HC: honeycombing; QILD: QLF+GG+HC; TLC: total lung capacity.