Pulmonary function test results
| Cohort 1 | Cohort 2 | All | |||||||
| BL | Change from BL | BL | Change from BL | BL | Change from BL | ||||
| 24 weeks | 48 weeks | 24 weeks | 48 weeks | 24 weeks | 48 weeks | ||||
| FVC | |||||||||
| Subjects n | 53 | 45 | 38 | 36 | 30 | 28 | 89 | 75 | 66 |
| FVC L | |||||||||
| Mean±se | 2.60±0.10 | −0.08±0.03 | −0.15±0.04 | 2.93±0.16 | −0.07±0.05 | −0.13±0.06 | 2.73±0.08 | −0.08±0.02 | −0.14±0.04 |
| Median (range) | 2.37 (1.50–4.22) | −0.08 (−0.54–0.36) | −0.17 (−0.68–0.57) | 2.62 (1.32–5.51) | −0.08 (−0.37–0.82) | −0.11 (−0.75–0.64) | 2.53 (1.32–5.51) | −0.08 (−0.54–0.82) | −0.14 (−0.75–0.64) |
| FVC % predicted | |||||||||
| Mean±se | 62.8±1.80 | −1.80±0.65 | −3.00±1.04 | 72.7±2.69 | −1.71±1.15 | −2.25±1.34 | 66.8±1.56 | −1.77±0.60 | −2.69±0.82 |
| Median (range) | 63.2 (42.6–89.6) | −1.54 (−15.7–6.8) | −3.62 (−15.1–10.7) | 69.4 (52.9–111.7) | −1.55 (−13.2–17.3) | −1.89 (−16.7–14.1) | 65.9 (42.6–111.7) | −1.54 (−15.7–17.3) | −3.30 (−16.7–14.1) |
| DLCO % predicted, Hb corrected | |||||||||
| Subjects n | 53 | 43 | 37 | 36 | 29 | 27 | 89 | 72 | 64 |
| Mean±se | 48.3±1.7 | −4.71±0.88 | −4.50±0.96 | 49.7±2.4 | −2.01±0.99 | −5.61±1.08 | 49.8±1.41 | −3.62±0.67 | −4.9±0.72 |
| Median (range) | 47.0 (31.1–94.5) | −4.55 (−19.7–7.4) | −3.50 (−19.0–11.6) | 49.5 (30.4–89.6) | −3.24 (−11.1–10.1) | −4.91 (−20.5–4.4) | 47.4 (30.4–94.5) | −3.68 (−19.7–10.1) | −4.71 (−20.5–11.6) |
| FEV1% predicted | |||||||||
| Subjects n | 53 | 45 | 38 | 36 | 30 | 28 | 89 | 75 | 66 |
| Mean±se | 69.4±1.80 | −2.36±0.76 | −3.44±1.08 | 79.7±2.54 | −1.43±1.33 | −1.65±1.32 | 73.6±1.57 | −1.99±0.70 | −2.68±0.84 |
| Median (range) | 72.5 (47.5–103.0) | −2.28 (−15.4–9.7) | −3.65 (−17.0–10.8) | 77.9 (60.5–115.4) | −2.36 (−19.2–19.4) | −1.59 (−15.6–17.7) | 74.4 (47.5–115.4) | −2.35 (−19.2–19.4) | −2.16 (−17.0–17.7) |
| TLC % predicted | |||||||||
| Subjects n | 53 | 43 | 37 | 36 | 30 | 28 | 89 | 73 | 65 |
| Mean±se | 65.2±1.6 | −1.55±1.21 | −2.89±1.20 | 71.6±2.5 | −1.86±0.92 | −4.32±1.16 | 67.8±1.41 | −1.68±0.80 | −3.51±0.84 |
| Median (range) | 64.3 (43.1– 98.9) | −1.04 (−21.9– 13.8) | −3.92 (−15.0– 17.9) | 68.9 (53.3– 118.5) | −1.93 (−15.5– 9.7) | −4.23 (−18.3– 8.9) | 65.3 (43.1– 118.5) | −1.79 (−21.9– 13.8) | −4.02 (−18.3– 17.9) |
All data are from observed values. BL: baseline; FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon dioxide; Hb: haemoglobin; FEV1: forced expiratory volume in 1 s; TLC: total lung capacity.