TABLE 1

Survival associations for clinicopathological factors including morphological characteristics of the SQCCs

OverallEvents: overall survivalOverall survival monthsp-valueEvents: DFSDFS monthsp-value
Subjects54118069.3±2.416272.5±2.5
Age
 Below median2556978.4±3.30.0027873.7±3.40.855
 Above median28611160.7±2.98468.6±3.3
Sex
 Male44215765.8±2.40.07214367.4±2.50.026
 Female992377.9±5.91986.3±4.9
pT
 1941195.8±4.1<0.0011393.5±4.3<0.001
 233611764.8±2.610167.0±2.7
 3924351.3±5.04150.7±5.4
 419930.8±5.6732.1±6.2
pN
 02607672.0±3.0<0.0017174.5±3.10.011
 11725571.5±4.45371.0±4.4
 21024448.8±4.43851.9±4.8
 31111.7±00
pM
 053617769.6±2.40.05116172.5±2.50.916
 15327.8±10.8146.0±10.0
Stage
 11914875.8±3.3<0.0014081.4±3.3<0.001
 21986671.3±3.96868.3±4.0
 31476350.7±3.85355.0±4.0
 45327.8±10.8146.0±10.0
Histological subtype
 Nonkeratinising34410271.5±3.10.0379475.1±3.20.340
 Keratinising1787462.1±3.86165.8±4.1
 Basaloid18468.8±6.9755.7±8.5
Budding (per HPF)
 03569377.0±3.1<0.00110273.4±3.10.527
 <51637259.0±4.05168.4±4.4
 ≥5221552.5±8.6960.9±10.0
Budding (per 10 HPFs)
 03569377.0±3.1<0.00110273.7±3.10.053
 <151014163.3±5.02774.1±5.3
 ≥15844650.2±4.83357.8±5.5
Smallest tumour cell nest (overall)
 Single cells924553.5±4.53262.4±4.9
 <5 cells1666462.1±3.80.0015566.9±4.40.383
 5–15 cells1143377.2±4.93077.9±5.0
 >15 cells1663878.0±3.94571.3±4.3
Smallest tumour cell nest (invasive margin)
 Single cells974855.0±4.63561.7±5.0
 <5 cells923961.1±5.40.0012672.1±5.80.446
 5–15 cells1413973.6±4.94470.3±5.0
 >15 cells2085375.5±3.65772.1±3.7
Nuclear size (overall)
 Small31010364.4±2.80.7479465.5±3.00.501
 Medium1043267.5±4.72772.3±4.6
 Large1274571.3±4.44172.9±4.6
Stromal content
 Low1523278.8±4.40.0114072.6±4.60.143
 Moderate1566062.0±4.55566.8±4.6
 High1735868.7±4.05172.5±4.0
Tumour grade
 12475781.8±3.4<0.0016675.2±3.70.060
 22399362.6±3.27669.6±3.6
 3432743.0±6.21752.5±7.8
  • Data are presented as n or mean±se, unless otherwise stated. SQCC: squamous cell carcinoma; DFS: disease-free survival; pT: primary tumour; pN: regional lymph nodes; pM: distant metastasis; HPF: high-power field. Not all parameters could be assessed in all patients.