TABLE 2

The diagnostic accuracy of nasal nitric oxide (nNO), high-speed video microscopy analysis (HSVMA) and transmission electron microscopy (TEM) analysis to diagnose primary ciliary dyskinesia

 nNO ≤30 nL·min−1HSVMATEM
Subjects#301 (47)625 (98)368 (57)
Positive patients34 (45)60 (80)71 (95)
Negative patients+267 (47)565 (100)297 (52)
True positive316056
True negative257526297
False positive10390
False negative3015
Sensitivity (95% CI)0.91 (0.76–0.98)1.00 (0.94–1.00)0.79 (0.68–0.88)
Specificity (95% CI)0.96 (0.93–0.98)0.93 (0.91–0.95)1.00 (0.99–1.00)
PPV (95% CI)0.76 (0.60–0.88)0.61 (0.50–0.70)1.00 (0.94–1.00)
NPV (95% CI)0.99 (0.97–1.00)1.00 (0.99–1.00)0.95 (0.92–0.97)
  • Data are presented as n (%) or n, unless otherwise stated. Data were analysed for patients with conclusive positive or negative results who underwent the individual tests. PPV: positive predictive value; NPV: negative predictive value. #: n=641; : n=75; +: n=566.