TABLE 3

Pulmonary function tests and 6-min walking distance (6MWD): baseline values and change from baseline on day 57

PlaceboPRM-151
1 mg·kg−15 mg·kg−110 mg·kg−1All doses
Subjects655414
FVC L
 Baseline2.15±0.642.96±0.852.78±0.732.97±0.712.90±0.71
 Day 57 change from baseline−0.063±0.1160.058±0.1640.060±0.0740.078±0.2100.064±0.142
FVC % pred
 Baseline63.2±16.782.4±15.580.0±7.872.8±14.378.8±12.5
 Day 57 change from baseline−1.5±3.32.4±4.62.8±3.01.8±5.32.4±4.0
DLCO %     
 Baseline35.2±8.441.2±10.552.8±9.846.0±7.246.7±10.1
 Day 57 change from baseline−2.3±2.10.2±3.3−4.0±6.8−1.5±3.8−1.8±4.9
FEV1 %
 Baseline68.8±17.785.8±16.887.0±11.973.0±12.182.6±14.3
 Day 57 change from baseline−1.7±4.32.6±4.32.4±1.10.3±3.81.9±3.2
6MWD m
 Baseline458±73457±157470±101439±63456±109
 Day 57 change from baseline−11±51−11±636±4335±458±51
  • Data are presented as n or mean±sd. FVC: forced vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; FEV1: forced expiratory volume in 1 s.