Lung squamous cell carcinoma grade according to sum of scores for tumour budding and nest size
| Morphologic feature | Score | Definition |
| Tumour budding | 1 | No budding in 10 HPFs |
| 2 | <15 budding foci per 10 HPFs | |
| 3 | ≥15 budding foci per 10 HPFs | |
| Tumour nest size | 1 | >15 cells (large nest size) |
| 2 | 5–15 cells (intermediate nest size) | |
| 3 | <5 (or 2–4) cells (small nest size) | |
| 4 | Single cell invasion | |
| Combined score | 2–3 | Grade 1 (well differentiated) |
| 4–6 | Grade 2 (moderately differentiated) | |
| 7 | Grade 3 (poorly differentiated) |
HPF: high-power field. Reproduced and modified from [33].