TABLE 5

Patient characteristics and quality of life in the validation cohort according to the four clusters

Cluster 1:
Pseudomonas
Cluster 2:
“Other chronic infection”
Cluster 3:
“Daily sputum”
Cluster 4:
“Dry bronchiectasis”
Overall p-value
Demographics and comorbidities
 Age years70 (62–72)66 (57–74)65 (55–72)63 (55–75)0.7
 Male14 (46.6)10 (33.3)13 (43.3)11 (36.7)0.7
 BMI kg·m–224 (21–26)26 (22–30)25 (24–30)26 (22–30)0.8
 Smoker/ex-smoker9 (30)8 (27)9 (30)4 (13.3)0.4
 CCI >111 (37)10 (33)8 (27)12 (40)0.7
Disease severity
 BSI score12 (9–15)8 (5–11)6 (3–9)6 (4–8)0.0001
Radiological status
 Reiff score6 (3–10)3 (2–6)2 (2–5)3 (2–4)<0.0001
Clinical status
 Daily cough30 (100)28 (93)30 (100)19 (64)<0.0001
 Daily sputum29 (97)27 (90)30 (100)0 (0)<0.0001
 Prior history of haemoptysis8 (27)4 (13)3 (10)0 (0)0.02
 MRC breathlessness scale3 (2–5)3 (2–4)1 (1–2)1 (1–2)<0.0001
 Exacerbations in the previous year2 (1–5)2 (0–2)1 (0–1)1 (0–2)<0.0001
 At least one hospitalisation in the previous year20 (66.7)15 (50)5 (16.6)3 (10.0)<0.0001
Functional status
 FEV1 % predicted51 (35–76)61 (49–81)83 (65–97)93 (59–99)<0.0001
Microbiology
 Chronic infection with Pseudomonas aeruginosa30 (100)000<0.0001
 Chronic infection with other pathogens030 (100)00<0.0001
Quality of life
 SGRQ58.3 (38.6–70.3)44.3 (31.8–51.9)33.3 (25.6–37.1)36.6 (20–49.0)<0.0001
 Leicester Cough Questionnaire10 (9–16)13 (10–17)16 (14–19)13.2 (11.0–19.0)0.004
  • Data are presented as median (interquartile range) or n (%), unless otherwise stated. BMI: body mass index; CCI: Charlson Comorbidity Index; BSI: Bronchiectasis Severity Index; MRC: Medical Research Council; FEV1: forced expiratory volume in 1 s; SGRQ: St George's Respiratory Questionnaire.