TABLE 2

Pharmacokinetic parameters of ertapenem

StudyAUC0–24 h·mg·L−1Cmax mg·L−1Half-life hVolume of distribution LClearance L·h−1
1 g i.v. in MDR-TB patients544.9 (309–1130)127.5 (73.9–277.9)2.4 (2.047–3.528)7.3 (2.612–11.1)2.1 (0.0884–3.231)
1 g i.v. in healthy volunteers [18]572.1 (572–672)154.9 (145–175)4 (3.8–4.4)8.21.8
  • Data are presented as mean (range) and were calculated using KinFIT. AUC0–24: area under the concentration–time curve up to 24 h; Cmax: maximum observed plasma concentration; MDR-TB: multidrug-resistant tuberculosis.