TABLE 6

Antibody diagnosis of chronic pulmonary aspergillosis (CPA)

PopulationIntentionInterventionSoRQoERef.Comment
Cavitary or nodular  pulmonary infiltrate in  non-immunocompromised patientsDiagnosis or exclusion of CPAAspergillus IgG antibodyAII[42–44]IgG and precipitins test standardisation incomplete
Aspergillus precipitinsAII[29, 43, 45–47]Mostly in-house tests and poorly validated; uncertain sensitivity is the major problem
Aspergillus IgM antibodyDIII[48]Few data
Aspergillus IgA antibodyDIII[49, 50]
Intervention in context of asthma,  ABPA or CF patientsAspergillus IgE antibodyBII[10, 51]Often detectable in CCPA irrespective of underlying condition, with a raised total IgE
  • SoR: strength of recommendation; QoE: quality of evidence; ABPA: allergic bronchopulmonary aspergillosis; CF: cystic fibrosis; CCPA: chronic cavitary pulmonary aspergillosis.