TABLE 8

Oral triazole therapy of chronic pulmonary aspergillosis

Antifungal agent and doseStrength of recommendationQuality of evidence
Itraconazole 200 mg twice daily, adjust with  therapeutic drug monitoringAII
Voriconazole# 150–200 mg twice daily,  adjust with therapeutic drug monitoringAII
Posaconazole 400 mg twice daily  (liquid); 300 mg once daily (tablets)BII
  • #: lower doses advised in those aged >70 years, low weight, significant liver disease and those of North East Asian descent who may be slow metabolisers.