TABLE 3

Univariate and multivariate Cox regression models for progression-free survival (PFS) and overall survival regarding baseline and post-chemotherapy cell-free (cf)DNA plasma concentrations

OR (95% CI)p-valueAdjusted OR# (95% CI)p-value
PFS
 Baseline concentration1.0004 (1.0002–1.0006)0.0011.00025 (0.99998–1.00052)0.072
 Post-chemotherapy concentration1.0001 (0.9997–1.0005)0.6361.00005 (0.99966–1.00044)0.800
Overall survival
 Baseline concentration1.00042 (1.00018–1.00066)0.0011.00030 (1.00003–1.00057)0.028
 Post-chemotherapy concentration1.00037 (0.99998–1.00077)0.0631.00035 (0.99994–1.00075)0.094
  • #: adjusted for age, stage, performance status at diagnosis and response rate;: for each increment of 1 ng·mL−1.