TABLE 2

Multivariate analysis results of lymphocyte infiltration tumour islet/stroma (TI/S) ratio and clinicopathological variables#

Hazard ratio (95% CI)p-value
TI/S CD3+
 <Median1
 >Median0.65 (0.41–1.02)0.064
TI/S CD8+
 <Median1
 >Median0.481 (0.30–0.764)0.002
TI/S Foxp3+
 <Median1
 >Median3.91 (2.33–6.55)<0.001
Tumour size
 <5 cm1
 ≥5 cm2.19 (1.39–3.44)0.001
Overall p-stage
 IA and IB1
 IIA and IIB1.8 (1.06–3.09)0.030
 IIIA1.9 (1.13–3.31)0.015
 Overall0.024
  • FoxP3: forkhead box P3; p: pathologically confirmed. #: the following were included as co-variates: tumour size, tumour stage, lymph node stage, World Health Organization overall stage, presence/absence of tumour involvement in resection margins and TI/S ratios for CD3+, CD8+ and Foxp3+ T-lymphocytes.