TABLE 4

Cell-free (cf)DNA as a tool to monitor the response to treatment

First author [ref.]	Method	Sample	Subjects	cfDNA concentration ng·mL⁻¹
				Before treatment	After treatment
				Before treatment	Progressive disease	Stable disease	Partial response
Kumar [15]	PicoGreen	Plasma	42	95±32.1	159.7	101.1	51.7
Gautschi [13]	Quantitative PCR	Serum	91	39	Increased
Gautschi [13]	Quantitative PCR	Plasma		3.7		Decreased	Decreased
Lee [14]	Quantitative PCR	Plasma	108	Tertile 1	+20.5%	+10.9%	+18.9%
				Tertile 2
				Tertile 3	−18.5%	−9.5%	−18.6%

Data are presented as n or mean±sd, unless otherwise stated.