TABLE 3

Baseline characteristics after stratification for multidimensional response clusters

Baseline	Very good responder	Good responder	Moderate responder	Poor responder
Patients n (%)	378 (18.3)	742 (35.9)	731 (35.4)	217 (10.5)
Age years	62.9±8.8	63.7±9.0	64.2±8.7	64.4±9.1
Sex % women	41.8	43.9	42.7	42.4
FEV₁ L	1.31±0.64	1.31±0.54	1.31±0.57	1.27±0.56
FEV₁ % predicted	47.4±20.2	48.9±17.8	48.8±18.3	47.9±18.8
K_CO % predicted	67.7±22.7	67.0±23.8	64.9±21.9	64.1±22.2
LTOT use % patients	21.7	15.9	12.2^#	12.4^#
P_aO₂ kPa	9.6±1.4	9.7±1.4	9.6±1.3	9.7±1.3
P_aCO₂ kPa	5.2±0.7	5.2±0.6	5.2±0.6	5.3±0.8
S_aO₂ %	94.9±2.6	95.0±2.4	95.1±2.1	95.0±2.1
MRC grade	3.7±1.1	3.3±1.1^#	3.2±1.1^#	3.2±1.1^#
Exacerbation <12 m n	2.5±2.6	2.1±2.5	2.0±2.4^#	2.0±1.9
Admission <12 m n	1.1±1.8	0.7±1.2^#	0.6±1.3^#	0.7±1.3^#
CC index points	1.4±1.2	1.4±1.2	1.4±1.1	1.4±1.1
BMI kg·m⁻²	26.3±5.6	25.9±5.5	25.1±5.0^#^,^¶	24.8±4.6^#^,^¶
FFMI kg·m⁻²	17.1±2.7	16.8±2.4	16.6±2.3^#	16.5±2.2^#
6MWD m	405±123	452±113^#	461±112^#	457±104^#
6MWD % predicted	63.3±17.4	71.4±15.6^#	72.3±16.0^#	71.7±15.7^#
PWR watts	68.2±32.3	73.5±31.4	72.9±30.5	70.4±28.3
PWR % predicted	50.5±22.7	59.1±27.0^#	57.7±24.3^#	57.3±26.3^#
V′_O₂ % predicted	64.2±24.6	70.5±32.7	68.3±31.1	69.8±34.1
Ventilation %MVV	84.3±22.3	84.0±21.2	83.9±20.8	87.2±22.6
CWRT s	295±173	320±225	326±265	296±238
COPM-P points	3.8±1.3	4.2±1.3^#	4.5±1.3^#^,^¶	4.5±1.4^#^,^¶
COPM-S points	3.2±1.6	3.6±1.7^#	4.0±1.7^#^,^¶	4.1±1.8^#^,^¶
HADS-A points	8.4±4.3	7.2±4.2^#	6.8±4.3^#	6.3±4.3^#^,^¶
≥8 points % patients	57.0	45.0^#	38.0^#^,^¶	36.0^#
HADS-D points	8.0±4.1	6.7±4.0^#	6.4±4.0^#	5.9±3.9^#^,^¶
≥8 points % patients	55.0	40.0^#	36.0^#	32.0^#
SGRQ points	61.5±15.2	53.6±16.5^#	50.2±17.1^#^,^¶	50.4±17.0^#
BODE index points	4.0±2.3	3.4±2.1^#	3.3±2.1^#	3.4±2.0^#
ADO index points	4.7±1.8	4.3±1.8^#	4.3±1.6^#	4.4±1.7
Inpatient/outpatient %	64/36	41/59^#	31/69^#^,¶	25/75^#^,^¶

Data are presented as mean±SD, unless otherwise stated. FEV₁: forced expiratory volume in 1 s; K_CO: transfer factor of the lung for carbon monoxide; P_aO₂: arterial oxygen tension; P_aCO₂: arterial carbon dioxide tension; S_aO₂: arterial oxygen saturation; MRC: Medical Research Council; CC index: Charlson Comorbidity index; BMI: body mass index; FFMI: fat-free mass index; 6MWD: 6-min walk distance; PWR: peak work rate; V′_O₂: oxygen uptake; MVV: maximal voluntary ventilation; CWRT: constant work-rate test; COPM-P: Canadian Occupational Performance Measure, performance score; COPM-S: Canadian Occupational Performance Measure, satisfaction score; HADS-A: Hospital Anxiety and Depression Scale, anxiety scores; HADS-D Hospital Anxiety and Depression Scale, depression scores; SGRQ: St George's Respiratory Questionnaire; BODE: body mass index, airflow obstruction, dyspnoea, exercise capacity; ADO: age, dyspnoea, airflow obstruction. ^#: p<0.01 versus very good responder cluster; ^¶: p<0.01 versus good responder cluster. No statistically significant differences in baseline characteristics between moderate responder and poor responder clusters.