Baseline characteristics according to morphological subtype
| Variable | Histology | p-value versus LCNEC | |||||
| LCNEC | SCLC | SqCC | AdC | SCLC | SqCC | AdC | |
| Patients n | 952 | 11 844 | 19 633 | 24 253 | |||
| Age years | |||||||
| Mean±sd | 65.5±10.5 | 66.7±9.7 | 68.8±9.4 | 64.6±10.7 | |||
| Median (IQR) | 66 (52–80) | 67 (53–81) | 70 (57–83) | 65 (49–81) | 0.14# | <0.001# | <0.001# |
| Sex | 0.01 | <0.001 | <0.001 | ||||
| Male | 595 (62.5) | 6903 (58.3) | 15 055 (76.7) | 13 404 (55.3) | |||
| Female | 357 (37.5) | 4941 (41.7) | 4578 (23.3) | 10 849 (44.7) | |||
| TNM stage | <0.001 | <0.001 | <0.001 | ||||
| I | 162 (17.0) | 370 (3.1) | 4745 (24.2) | 5318 (21.9) | |||
| II | 90 (9.5) | 223 (1.9) | 2497 (12.7) | 1705 (7.0) | |||
| III | 186 (19.5) | 3389 (28.6) | 7009 (35.7) | 5134 (21.2) | |||
| IV | 514 (54.0) | 7862 (66.4) | 5382 (27.4) | 12 096 (49.9) | |||
| Tumour stage | <0.001 | <0.001 | 0.002 | ||||
| T1 | 183 (19.2) | 879 (7.4) | 2665 (13.6) | 5394 (22.2) | |||
| T2 | 297 (31.2) | 3234 (27.3) | 7886 (40.2) | 7903 (32.6) | |||
| T3 | 118 (12.4) | 1077 (9.1) | 2890 (14.7) | 2570 (10.6) | |||
| T4 | 266 (27.9) | 4933 (41.6) | 5607 (28.6) | 6650 (27.4) | |||
| Tx | 88 (9.2) | 1721 (14.6) | 585 (2.9) | 1736 (7.2) | |||
| Nodal stage | <0.001 | <0.001 | 0.03 | ||||
| N0 | 359 (37.7) | 2042 (17.2) | 8616 (43.9) | 10 227 (42.2) | |||
| N1 | 96 (10.1) | 509 (4.3) | 2289 (11.7) | 2033 (8.4) | |||
| N2 | 314 (33.0) | 6023 (50.9) | 6478 (33.0) | 7645 (31.5) | |||
| N3 | 183 (19.2) | 3270 (27.6) | 2250 (11.5) | 4348 (17.9) | |||
Data are presented as n (%) unless otherwise stated. LCNEC: large cell neuroendocrine carcinoma; SCLC: small cell lung carcinoma; SqCC: squamous cell carcinoma; AdC: adenocarcinoma; IQR: interquartile range; T: tumour; N: node; M: metastasis. #: Mann–Whitney U-test.