Questionnaires
| Severe nonsmoking asthma | Smokers and ex-smokers with severe asthma | Mild/moderate nonsmoking asthma | Unadjusted p-value# | |
| Subjects n | 311 | 110 | 88 | |
| ACQ | ||||
| Mean ACQ5 | 2.28±0.07 (n=277) | 2.23±0.12 (n=96) | 0.86±0.07 (n=85) | <0.001 |
| Mean ACQ7 | 2.67±0.08 (n=277) | 2.62±0.12 (n=96) | 1.01±0.07 (n=85) | <0.001 |
| AQLQ | ||||
| Total | 4.48±0.07 (n=276) | 4.44±0.13 (n=92) | 5.84±0.1 (n=84) | <0.001 |
| Symptoms | 4.46±0.08 (n=276) | 4.36±0.14 (n=92) | 5.87±0.1 (n=84) | <0.001 |
| Emotional | 4.63±0.1 (n=276) | 4.52±0.16 (n=92) | 5.98±0.13 (n=84) | <0.001 |
| Environmental stimuli | 4.69±0.09 (n=276) | 4.57±0.16 (n=92) | 5.63±0.14 (n=84) | <0.001 |
| Activity limitation | 4.35±0.07 (n=276) | 4.45±0.13 (n=92) | 5.81±0.11 (n=84) | <0.001 |
| HADS | ||||
| Total | 12.33±0.54 (n=223) | 13.64±1.01 (n=72) | 7.01±0.7 (n=70) | <0.001 |
| Anxiety | 6.94±0.3 (n=223) | 7.71±0.54 (n=72) | 4.24±0.41 (n=70) | <0.001 |
| Depression | 5.39±0.28 (n=223) | 5.93±0.56 (n=72) | 2.77±0.39 (n=70) | <0.001 |
| SNOT20 (total) | 31.76±1.01 (n=283) | 32.12±1.92 (n=97) | 15.42±1.42 (n=83) | <0.001 |
| ESS (total) | 7.48±0.26 (n=277) | 7.95±0.47 (n=95) | 5.49±0.41 (n=85) | <0.001 |
| MARS (total) | 22.44±0.14 (n=278) | 22.17±0.29 (n=94) | 21.35±0.4 (n=84) | 0.002 |
Data are presented as mean±se, unless otherwise stated. ACQ: Asthma Control Questionnaire; AQLQ: Asthma Quality of Life Questionnaire; HADS: Hospital Anxiety and Depression Score; SNOT20: Sino-nasal Outcome Test 20; ESS: Epworth Sleepiness Scale; MARS: Medication Adherence Report Scale. #: severe asthma (nonsmoking asthma group and smokers and ex-smokers with severe asthma group combined) versus mild/moderate nonsmoking asthma group.