Asthma quality of life, exacerbations and control
School-aged | Preschool | |||||
Severe asthma cohort | Mild/moderate asthma cohort | p-value | Severe wheeze cohort | Mild/moderate wheeze cohort | p-value | |
Patients n | 97 | 43 | 77 | 54 | ||
Asthma-related quality of life | ||||||
PAQLQ | ||||||
Total mean | 4.77±0.15 (n=91) | 5.8±0.19 (n=39) | <0.001 | NA | NA | NA |
Total z-score | −0.22±0.1 (n=91) | 0.51±0.14 (n=39) | <0.001 | NA | NA | NA |
Symptoms | 4.57±0.16 (n=91) | 5.77±0.19 (n=39) | <0.001 | NA | NA | NA |
Emotion | 4.91±0.18 (n=91) | 6.03±0.19 (n=39) | <0.001 | NA | NA | NA |
Activity limitation | 3.91±0.15 (n=91) | 4.57±0.19 (n=39) | 0.012 | NA | NA | NA |
PACQLQ | ||||||
Total | NA | NA | NA | 4.27±0.18 (n=77) | 6.04±0.18 (n=52) | <0.001 |
Total z-score | NA | NA | NA | −0.46±0.09 (n=77) | 0.66±0.12 (n=52) | <0.001 |
Exacerbations | ||||||
Exacerbations in previous year | 3 (2–5) (n=97) | 1.05 (0–2) (n=43) | <0.001 | 3.91 (1–6) (n=77) | 1.83 (0–2.8) (n=54) | <0.001 |
Asthma control | ||||||
ACT >12 years | ||||||
Total | 15.49±0.63 (n=67) | 20.25±0.81 (n=24) | <0.001 | NA | NA | NA |
Total z-score | −0.25±0.12 (n=67) | 0.69±0.17 (n=24) | <0.001 | NA | NA | NA |
Total ≤19 | 50/67 (74.6%) | 7/24 (29.2%) | <0.001 | NA | NA | NA |
Childhood ACT | ||||||
Total | 16.38±0.98 (n=29) | 19.22±1.01 (n=18) | 0.061 | 15.2±0.79 (n=41) | 23±0.67 (n=22) | <0.001 |
Total z-score | −0.26±0.16 (n=29) | 0.23±0.2 (n=18) | 0.065 | −0.47±0.13 (n=41) | 1.01±0.16 (n=22) | <0.001 |
Total ≤19 | 19/29 (65.5%) | 7/18 (38.9%) | 0.078 | 32/41 (78%) | 4/22 (18.2%) | <0.001 |
Combined ACT# | ||||||
z-score | −0.26±0.1 (n=95) | 0.47±0.13 (n=41) | <0.001 | −0.47±0.13 (n=41) | 1.01±0.16 (n=22) | <0.001 |
Data are presented as mean±se, median (interquartile range) or n/N (%), unless otherwise stated. p-values were calculated using a Kruskall–Wallis test or Pearson's Chi-squared test. PAQLQ: Paediatric Asthma Quality of Life Questionnaire; PACQLQ: Paediatric Asthma Caregiver's Quality of Life Questionnaire; ACT: Asthma Control Test (used for participants >12 years; children aged 4–11 years completed the childhood ACT); NA: not applicable. #: to allow the joint analysis of the ACT and childhood ACT, data were transformed to improve symmetry and then z-scores were calculated.