Analysis of the sputum inflammatory marker data: ratio of AZD5069 80 mg twice daily to placebo in the pharmacodynamics analysis set
| Baseline | End of treatment | ANCOVA | p-value | ||||||||
| Ratio of end of treatment to baseline | Ratio of AZD5069 80 mg twice daily to placebo | ||||||||||
| Subjects n | Geo mean | CV % | Subjects n | Geo mean | CV % | Subjects n | Ratio (90% CI) | Subjects n | Ratio (90% CI) | ||
| IL-1β pg·mL−1 | |||||||||||
| Placebo | 25 | 924.7 | 318.6 | 25 | 863.2 | 424.5 | 25 | 0.9 (0.7–1.3) | |||
| AZD5069 | 22 | 1384.3 | 319.5 | 22 | 847.2 | 357.3 | 22 | 0.6 (0.4–0.9) | 47 | 0.7 (0.4–1.1) | 0.220 |
| IL-6 pg·mL−1 | |||||||||||
| Placebo | 25 | 122.8 | 163.4 | 25 | 108.4 | 155.2 | 25 | 0.8 (0.6–1.1) | |||
| AZD5069 | 22 | 193.0 | 216.5 | 22 | 655.8 | 152.4 | 22 | 3.7 (2.8–4.8) | 47 | 4.5 (3.1–6.5) | <0.001 |
| RANTES pg·mL−1 | |||||||||||
| Placebo | 25 | 19.8 | 132.1 | 25 | 20.9 | 124.8 | 25 | 1.1 (0.9–1.3) | |||
| AZD5069 | 22 | 18.0 | 97.4 | 22 | 18.1 | 113.9 | 22 | 1.0 (0.8–1.2) | 47 | 0.9 (0.7–1.3) | 0.670 |
| MCP-1 pg·mL−1 | |||||||||||
| Placebo | 25 | 600.8 | 106.8 | 25 | 570.9 | 77.4 | 25 | 0.9 (0.8–1.1) | |||
| AZD5069 | 22 | 685.2 | 74.0 | 22 | 603.6 | 55.4 | 22 | 0.9 (0.8–1.1) | 47 | 1.0 (0.8–1.3) | 0.968 |
| TNF-α pg·mL−1 | |||||||||||
| Placebo | 25 | 48.2 | 489.5 | 25 | 43.6 | 884.2 | 25 | 1.0 (0.7–1.2) | |||
| AZD5069 | 22 | 67.7 | 393.9 | 22 | 87.9 | 452.5 | 22 | 1.3 (0.9–1.8) | 47 | 1.4 (0.9–2.2) | 0.193 |
| GRO-α pg·mL−1 | |||||||||||
| Placebo | 25 | 8170.2 | 487.4 | 25 | 7722.8 | 277.8 | 25 | 0.9 (0.7–1.1) | |||
| AZD5069 | 22 | 13 883.9 | 276.4 | 22 | 34 228.8 | 152.6 | 22 | 2.8 (2.1–3.7) | 47 | 3.2 (2.2–4.8) | <0.001 |
| IL-8 pg·mL−1 | |||||||||||
| Placebo | 26 | 16 682.3 | 162.7 | 26 | 13 362.1 | 236.8 | 26 | 0.8 (0.6–1.0) | |||
| AZD5069 | 22 | 19 924.9 | 170.7 | 22 | 16 116.9 | 162.1 | 22 | 0.8 (0.6–1.1) | 48 | 1.0 (0.7–1.5) | 0.917 |
| Neutrophil elastase activity μmol·L−1·h−1 | |||||||||||
| Placebo | 5 | 11.9 | 35 745.8 | 5 | 19.6 | 131 038.6 | 5 | 2.0 (0.6–6.4) | |||
| AZD5069 | 4 | 2.9 | 775.1 | 4 | 1.2 | 239.9 | 4 | 0.3 (0.1–1.3) | 9 | 0.2 (0.0–1.1) | 0.111 |
Geo mean: geometric mean; CV: coefficient of variation; IL: interleukin; MCP: monocyte chemotactic protein; TNF: tumour necrosis factor; GRO: growth-regulated oncogene.