Model | Subjects n | Consultations for wheezing illnesses | Subjects n | Prescriptions of: | ||||
Inhaled corticosteroids | Short-acting β2-agonists | |||||||
IRR (95% CI) | p-value | IRR (95% CI) | p-value | IRR (95% CI) | p-value | |||
1 | 1033 | 1.035 (1.009–1.062) | 0.01 | 1051 | 1.076 (1.047–1.106) | <0.01 | 1.046 (1.023–1.069) | <0.01 |
2 | 873 | 1.033 (1.001–1.065) | 0.04 | 888 | 1.097 (1.063–1.133) | <0.01 | 1.057 (1.031–1.084) | <0.01 |
3 | 524 | 1.002 (0.962–1.044) | 0.92 | 524 | 1.109 (1.061–1.160) | <0.01 | 1.073 (1.036–1.111) | <0.01 |
4 | 705 | 1.022 (0.986–1.059) | 0.23 | 717 | 1.077 (1.037–1.120) | <0.01 | 1.058 (1.025–1.084) | <0.01 |
IRR: incidence rate ratio; 1: univariable; 2: daycare, breastfeeding, older siblings, smoke exposure during pregnancy, pet keeping, socioeconomic status, ethnicity and maternal age; 3: all variables of model 2 and weight and height at the 5-year visit; 4: all variables of model 2 and resistance of the respiratory system.