TABLE 1

Subject characteristics

DemographicCOPDControlsp-value
Subjects n1969316
Age67±958±11<0.0001
Age categories
 Age ≤55 years236 (12)132 (43)<0.0001
 Age >55 and <65528 (27)84 (26)NS
 Age ≥65 years1205 (61)100 (31)<0.0001
Male1734 (89)194 (56)
Current smoker603 (33)164 (48)<0.0001
Pack-years75±4533±22<0.0001
Spirometry
 FEV1 % predicted52±21100±15<0.0001
 GOLD I221 (11)
 GOLD II757 (38)
 GOLD III692 (35)
 GOLD IV299 (15)
BODE index3 (1–5)
 BODE 0–2795 (42)
 BODE 3–4528 (28)
 BODE 5–6319 (17)
 BODE 7–10261 (14)
BMI27.2±5.427.8±4.90.115
 ≤21 kg·m−2268 (14)29 (9)NS
 >21–<25 kg·m−2355 (18)59 (19)NS
 ≥25–<30 kg·m−2759 (39)130 (42)NS
 ≥30–<35 kg·m−2409 (21)71 (22)NS
 ≥35 kg·m−2175 (9)27 (9)NS
Comorbidities per patient#
 Comorbidities (whole)4 (2–7; 0–20)2 (0–3; 0–14)<0.0001
 Comorbidities by age
  ≤55 years4 (1–6; 0–14)1 (0–2; 0–7)<0.0001
  >55–<65 years4 (2–6; 0–19)2 (1–4; 0–8)<0.0001
  ≥65 years5 (3–7; 0–20)2 (3–4; 0–14)<0.0001
 Comorbidities by sex
  Male4 (2–7; 0–20)2 (1–3; 0–14)<0.0001
  Female3 (1–5; 0–14)1 (0–3; 0–8)<0.0001
  • Data are presented as mean±sd, n (%) or median (interquartile range), unless otherwise stated. #: number of comorbidities per patient presented as median (interquartile range; range). COPD: chronic obstructive pulmonary disease; FEV1: forced expiratory volume in 1 s; GOLD: Global Initiative on Obstructive Lung Disease; BODE: body mass index, airflow obstruction, dyspnoea and exercise capacity; BMI: body mass index; NS: not significant.