Cardiopulmonary exercise testing parameters in interstitial lung disease (ILD) patients plus or minus pulmonary vascular dysfunction (PVD)
| ILD+PVD# | ILD−PVD¶ | p-value | ||||
| Rest | Peak exercise | Rest | Peak exercise | Rest | Peak exercise | |
| mPAP–Q´T slope mmHg·min·L−1 | 4.1±0.3 | 1.9±0.2 | <0.001 | |||
| Maximum workload W | 75±9 | 94±12 | 0.223 | |||
| V´O2 at AT % | 30±2 | 38±2 | 0.025 | |||
| Peak V´O2 mL·kg−1·min−1 | 13±1 | 17±1 | 0.012 | |||
| Peak V´O2 % predicted | 56±2 | 66±5 | 0.075 | |||
| Q´T L·min−1 | 4.5±0.4 | 9.3±0.6 | 5.4±0.3 | 12.5±0.8 | 0.103 | 0.006 |
| CI L·min−1·m−2 | 2.4±0.2 | 4.9±0.3 | 2.9±0.2 | 6.6±0.3 | 0.082 | 0.001 |
| SV mL | 59±4 | 73±5 | 73±6 | 96±6 | 0.057 | 0.007 |
| HR beats·min−1 | 78±4 | 131±7 | 75±3 | 132±5 | 0.575 | 0.912 |
| O2 pulse | 7.9±0.6 | 9.7±0.7 | 0.078 | |||
| mPAP mmHg | 23±1 | 43±3 | 17±1 | 31±2 | 0.001 | 0.001 |
| mPCWP mmHg | 7±1 | 13±3 | 4±1 | 9±1 | 0.015 | 0.252 |
| PVR Wood units | 3.2±0.4 | 1.8±0.1 | 0.001 | |||
| V´Emax/MVV % | 84±5 | 83±6 | 0.952 | |||
| VD/VT % | 41±2 | 39±2 | 34±2 | 30±2 | 0.035 | 0.008 |
| V´E/V´CO2 at AT | 45±2 | 38±1 | 0.015 | |||
| PETCO2 at AT | 31±1 | 35±1 | 0.085 | |||
| SO2 % | 96±1 | 89±2 | 96±1 | 89±2 | 0.820 | |
| PaO2 mmHg | 81±4 | 62±5 | 82±3 | 63±5 | 0.906 | |
| PA−aO2 mmHg | 61±8 | 50±5 | 0.287 | |||
Data are presented as mean±sem, unless otherwise stated. mPAP: mean pulmonary arterial pressure; Q´T: cardiac output; V´O2: oxygen consumption; AT: anaerobic threshold; CI: cardiac index; SV: stroke volume; HR: heart rate; mPCWP: mean pulmonary capillary wedge pressure; V´Emax: maximum minute ventilation at peak exercise; MVV: maximum voluntary ventilation; VD: dead space volume; VT: tidal volume; V´E: minute ventilation; V´CO2: carbon dioxide production; PETCO2: end-tidal carbon dioxide tension; SO2: oxygen saturation; PaO2: arterial oxygen tension; PA−aO2: alveolar–arterial oxygen tension difference. #: n=15; ¶: n=12. Bold indicates statistical significance.