TABLE 3

Diagnostic accuracy in in patients with different asthma phenotypes

Obesity

Atopy

Asthma severity

Smoking status

Nonobese

Obese

p-value

Nonatopic

Atopic

p-value

Mild–moderate

Severe

p-value

Never-smoker

Ex- or current smoker

p-value

Eosinophilia (<3%/≥3%)

154/82

66/34

0.90

153/74

67/42

0.28

161/58

58/57

<0.01

103/51

117/65

0.62

F_eNO

0.83 (0.77–0.88)

0.78 (0.68–0.89)

0.46

0.83 (0.77–0.89)

0.78 (0.69–0.88)

0.40

0.81 (0.74–0.88)

0.83 (0.75–0.91)

0.67

0.84 (0.77–0.90)

0.81 (0.73–0.88)

0.52

Blood eosinophils

0.83 (0.77–0.89)

0.82 (0.73–0.91)

0.82

0.83 (0.77–0.89)

0.83 (0.74–0.91)

0.99

0.82 (0.76–0.89)

0.80 (0.72–0.89)

0.73

0.86 (0.79–0.93)

0.80 (0.73–0.87)

0.23

IgE

0.73 (0.67–0.80)

0.59 (0.47–0.70)

0.03

0.75 (0.68–0.82)

0.57 (0.46–0.68)

<0.01

0.68 (0.61–0.76)

0.66 (0.56–0.76)

0.70

0.64 (0.55–0.73)

0.74 (0.66–0.81)

0.13

F_eNO + blood eosinophils

0.88 (0.83–0.93)

0.85 (0.76–0.93)

0.55

0.88 (0.82–0.92)

0.85 (0.77–0.93)

0.63

0.86 (0.81–0.92)

0.85 (0.78–0.92)

0.81

0.88 (0.82–0.94)

0.86 (0.80–0.92)

0.64

Data are presented as n or area under the curve (AUC) (95% CI), unless otherwise stated. AUC (95% CI) is given per biomarker in every subgroup. The difference between the AUCs for every biomarker is compared within the separate subgroups and the result depicted as p-value. Bold type represents statistical significance. F_eNO: exhaled nitric oxide fraction; Ig: immunoglobulin.