TABLE 2

Top 25th percentile of comorbidities with highest number of links

ComorbidityPrevalence %Degrees at p-value cut-offAssociation with patient-centred outcome [ref.]
p≤0.01p≤0.001p≤0.0001
Systemic hypertension52.4282423Response to PR [16]
Hyperlipidaemia443.5221913
Coronary artery disease30.3342824Mortality [13], response to PR [16]
Degenerative joint disease298.8322720QOL [14]
BPH276.6302619
DM221.611QOL [14]
GORD187.7242016AE [41]
Depression176.8282516AE [17]
Peripheral arterial diseases176.71610
Congestive heart failure165.7373126Mortality [13]
Substance abuse143.9201612
Atrial fibrillation/flutter13252015Mortality [13]
Anxiety121.9231612Mortality (females) [13], AE [17]
Cerebrovascular accident110.7231811
Erectile dysfunction10.4231715
Pulmonary hypertension10.2211712Hospitalisation [42]
OSA10.1231711Mortality [40]
Osteoporosis8.411
Bipolar/schizophrenia87.8251912
Pulmonary fibrosis6.1231311Mortality [13]
Gout4.226
DM with neuropathy4211710Mortality [13], QOL [14]
Dementia32.619138
  • PR: pulmonary rehabilitation; QOL: quality of life; BPH: benign prostatic hypertrophy; DM: diabetes mellitus; GORD: gastro-oesophageal reflux disease; AE: acute exacerbations; OSA: obstructive sleep apnoea.