TABLE 1

Comparison of key PSG and ventilatory control parameters with methadone and buprenorphine therapy

MethadoneBuprenorphine
Central apnoea index per h29.10.7
OSAHI per h41.141.2
Overall AHI per h70.241.9
REM-AHI per h44.757.5
Total sleep time min440527
Supine sleep %8494
Supine REM %10.44.3
Arousal index per h23.29.1
T90 min39.915.2
ODI per h60.334.0
HCVR L·min·−1·mmHg−12.101.51
HVR L·min−1·mmHg−14.572.21
  • OSAHI: obstructive sleep apnoea–hypopnoea index; AHI: apnoea–hypopnoea index; REM: rapid eye movement sleep; T90: sleep time with oxygen saturation measured by pulse oximetry <90%; ODI: index of oxygen desaturation >3%; HCVR: hypercapnic ventilatory response; HVR: hypoxic ventilatory response.