TABLE 1

Resting haemodynamics, right ventricular (RV) remodelling and function at 6 weeks

PH groupSham groupp-value
Subjects n136
Body weight kg31.9±5.630.6±2.20.59
Mean blood pressure mmHg63±1370±110.25
Heart rate beats·min−1100±16101±130.93
Right heart catheterisation
 RAP mmHg8±25±20.01
 RV end-diastolic pressure13±55±3<0.01
 Mean PAP mmHg34±914±2<0.01
 Cardiac index L·min−1·m−23.2±1.03.2±0.20.93
 TPR dyn·s·cm−5993±572349±610.01
 Cardiac power index W·m−2108±4245±6<0.01
Conductance measurements
 SVI mL·m−241±744±50.49
 RV stroke work mmHg·mL−11853±851881±2650.03
 dP/dtmax mmHg·s−1540±141306±72<0.01
 dP/dtmin mmHg·s−1−738±299−244±65<0.01
 Ees mmHg·mL−10.54±0.090.37±0.05<0.01
 Ea mmHg·mL−10.88±0.350.32±0.06<0.01
 Ees/Ea0.66±0.181.24±0.17<0.01
 Tau ms34±418±7<0.01
Echocardiography
 LVEF %51±262±3<0.01
 RV end-diastolic diameter cm2.1±0.61.4±0.30.02
 RV end-diastolic area index cm2·m−211.0±2.44.6±0.6<0.01
 RVFAC0.25±0.040.51±0.08<0.01
 RV myocardial performance index0.62±0.170.30±0.04<0.01
 TAPSE cm1.4±0.42.0±0.2<0.01
 RVFAC/sPAP mm·mmHg−10.63±0.053.05±0.32<0.01
 TAPSE/sPAP mm·mmHg−10.34±0.091.07±0.15<0.01