TABLE 1

Study settings and treatment protocols for the in vivo experiments in rats and mice

Study	Bleomycin-induced lung fibrosis				Silica-induced lung fibrosis
	Rat		Mouse		Mouse
Posology	Once daily, oral		Once daily, oral		Once daily, oral
Model	Preventive	Therapeutic	Preventive	Therapeutic	Preventive	Therapeutic
Dose mg·kg⁻¹	10, 30, 50	50	30, 60	30, 60	30, 100	30, 100
Study duration days	21	21	14	21	30	30
Compound administration days	0–21	10–21	0–14	7–21	0–30	10–30, 20–30