TABLE 1

Patients' characteristics at the time of surgical lung biopsy (SLB) according to aetiological groups

Idiopathic NSIPUCTD#CTDscHPp-valueWhole population
Subjects51322915127
Demographics
 Males/Females32/1911/2110/19+9/60.02062/65
 Non-/current or ex-smokers21/3023/917/127/80.04468/59
 Age years55.8±11.556.5±12.851.6±14.452.7±10.30.20654.7±12.5
Clinical symptoms
 NYHA functional class I–II/III–IV41/1025/724/511/40.871101/26
 Squawks45330.56015
 Digital clubbing189540.40236
Duration of symptoms months35.4±49.248.1±47.732.4±31.032.5±44.00.44537.7±44.5
Site of SLB0.963
 At least two lobes321919979
 A single lobe or unknown191310648
HRCT pattern, n0.375
 Subjects3723231194
 Suggestive or consistent with NSIP3622201088
 Suggestive of UIP11316
Pulmonary function tests
 Subjects49312715122
  FEV1 % predicted70.0±19.075.7±22.266.1±20.860.2±17.40.11569.4±20.4
  FEV1/FVC %85.2±9.683.5±8.285.1±9.982.9±8.50.83084.5±9.2
  FVC % predicted67.4±17.373.6±20.363.3±20.059.0±14.30.07167.1±18.8
  TLC % predicted70.6±17.573.8±15.766.6±20.261.4±13.80.08169.4±17.6
 Subjects46282413110
  DLCO % predicted50.0±13.854.9±17.347.2±14.444.0±18.90.23850.0±15.7
Bronchoalveolar lavage
 Subjects42282214106
 Lymphocytes %15.6±13.317.1±17.220.1±16.720.6±19.70.86117.6±15.9
 Neutrophils %10.7±11.512.3±14.415.5±15.27.0±9.20.19811.7±13.1
 Eosinophils %3.5±5.36.9±13.23.7±4.73.0±3.00.8354.4±8.1