Multivariate analysis: risk factors for early and late mortality in invasive pneumococcal pneumonia
| RRR (95% CI) | p-value | |
| Early mortality | ||
| Age (18–50 years versus >50 years) | 0.48 (0.17–1.33) | 0.157 |
| Male sex | 1.51 (0.76–3.02) | 0.24 |
| Previous pneumococcal vaccination | 1.16 (0.6–2.24) | 0.66 |
| Alcohol consumption | 2.28 (1.11–4.66) | 0.024 |
| Chronic heart disease | 2.71 (1.42–5.19) | 0.003 |
| Chronic liver disease | 0.85 (0.35–2.05) | 0.713 |
| Chronic neurological disease | 2.26 (1.05–4.85) | 0.037 |
| HIV infection | 1.77 (0.56–5.58) | 0.329 |
| Haematologic cancer | 1.93 (0.73–5.09) | 0.182 |
| Solid cancer | 2.13 (0.96–4.73) | 0.062 |
| High case fatality rate serotypes# | 1.98 (1.07–3.63) | 0.029 |
| Late mortality | ||
| Age (18–50 years versus >50 years) | 0.53 (0.22–1.31) | 0.17 |
| Male sex | 1.22 (0.59–2.51) | 0.24 |
| Previous pneumococcal vaccination | 0.7 (0.32–1.52) | 0.366 |
| Alcohol consumption | 2.25 (1.12–4.53) | 0.023 |
| Chronic heart disease | 0.65 (0.24–1.76) | 0.401 |
| Chronic liver disease | 0.91 (0.4–2.07) | 0.813 |
| Chronic neurological disease | 0.96 (0.28–3.33) | 0.954 |
| HIV infection | 4 (1.55–10.3) | 0.004 |
| Haematologic cancer | 3.07 (1.21–7.76) | 0.018 |
| Solid cancer | 4.18 (1.96–8.92) | <0.001 |
| High case fatality rate serotypes# | 1.81 (0.96–3.42) | 0.069 |
RRR: relative risk ratio. #: serotypes grouped as high case fatality rates are serotypes 3, 6A, 6B, 9N, 19A, 19F and 23F.