First author [ref.] | Strains | Cells | Method | Concentration range | Drugs | Cells | MIC | Δlog10 CFU reduction# |
Luna-Herrera [39] | 2 CI, MDR-TB | J774A.1 murine macrophages | GI | 0.06–2.0 μg·mL−1 | CLR | 2–3¶ | ||
2 CI | 2–3¶ | |||||||
1 H37Rv | 2¶ | |||||||
Rastogi [44] | H37Rv | PBMC-derived human macrophages | CFU counts | 4 μg·mL−1 | CLR | <1 | ||
Falzari [47] | Erdman | J774A.1 murine macrophages | CFU counts | 0.06, 0.32, 1.6, 8 μM | CLR | <1 | ||
CETH | <1 | |||||||
Tomioka [49] | Kurono MDR-TB | MM6 | CFU counts | 2.3 μg·mL−1 | CLR | MM6 | 1–2 | |
A549-II | A549 | 1–2 | ||||||
Sato [48] | Kurono MDR-TB | MM6 | CFU counts | 2.3 μg·mL−1 | CLR | MM6 | 1–2 | |
A549-II | A549 | 2 | ||||||
MIC determination | MM6 A549 | 5 μg·mL−1 2.5 μg·mL−1 |
MIC: minimal inhibitory concentration; CI: clinical isolate; MDR-TB: multidrug-resistant tuberculosis; J774A.1: murine monocyte macrophage cell line; GI: growth index; CLR: clarithromycin; PBMC: peripheral blood monocytic cells; CETH: cethromycin; MM6: Mono-Mac-6 human monocytic cell line; A549-II: type II human alveolar epithelial cell lines. #: results are read from graphs, therefore a certain error must be taken into account; ¶: not a log10 CFU reduction but log10 reduced growth measured using growth index.