TABLE 1

Summary of common genetic variants linked to idiopathic pulmonary fibrosis (IPF)

LocusGeneSNPIPF riskIPF survivalReference
2q14IL1RNrs408392Yes[29–31]
 rs419598Yes
  rs2637988Yes
3q26hTRrs6793295Yes[32]
4q13IL8rs4073Yes[33]
  rs2227307Yes
4q22FAM13Ars2609255Yes[32]
4q35TLR3rs3775291Harmful[34]
5p15TERTrs2736100Yes[32, 35]
6p21CDKN1Ars2395655YesHarmful[36]
6p21HLA-DRB1Yes[37]
6q24DSPrs2076295Yes[32]
7q22Intergenicrs47274443Yes[32]
10q24OBFC1rs11191865Yes[32]
11p15MUC5Brs35705950YesProtective[32, 38–43]
 MUC2rs7934606Yes[32]
 TOLLIPrs111521887Yes[40]
 TOLLIPrs5743894Yes[40]
 TOLLIPrs2743890YesProtective[40]
13q34ATP11Ars1278769Yes[32]
14q21MDGA2rs7144383Yes[40]
15q14–15Intergenicrs2034650Yes[32]
17q13TP53rs12951053NoHarmful[36]
 TP53rs12602273NoHarmful
17q21MAPTrs1981997Yes[32]
17q21SPPL2Crs17690703Yes[40]
19q13DPP9rs12610495Yes[32]
19q13TGFB1rs1800470NoHarmful[44, 45]