TABLE 3

Risk prediction models used in different lung cancer screening trials

ModelRisk factors includedPeriod of prediction of lung cancer diagnosis or deathReference for algorithm
LLP (detection)Age5 yearsRaji et al. [36]
Sex
Years of smoking
Family history of lung cancer by age of affected relatives
History of a previous cancer
History of pneumonia
History of exposure to asbestos
PLCO (detection)Age6 yearsTammemägi et al. [37]
Race/ethnicity
Education
Body mass index
Chronic obstructive pulmonary disease
Personal history of cancer
Family history of lung cancer
Smoking status (current versus former)
Smoking intensity (average cigarettes/day)
Smoking duration
Smoking quit time
NLST (death)Age5 yearsKovalchik et al. [38]
Sex
Ethnicity
Body-mass index
Pack-years of smoking
Years since smoking cessation
Presence of emphysema
First-degree relative with lung cancer