No current infection | Infected# | p-value | No NE activity | Free NE activity¶ | p-value | |
Subjects n | 33 | 31 | 32 | 32 | ||
Age years | 2.28±2.24+ | 3.53±1.92+ | 0.0200 | 2.93±2.19 | 2.97±2.27 | 0.9497 |
Sex female/male | 13/20 | 16/15 | 0.4515 | 18/14 | 11/21 | 0.1313 |
Phe508del homozygous | 17 (51.52) | 16 (51.61) | 1.0000 | 17 (53.13) | 16 (50.00) | 1.0000 |
IL-8 ng·mL-1 | 1.80 (0.43–2.85) | 1.88 (0.93–4.68) | 0.4848 | 1.03 (0.28–1.87)§ | 2.87 (1.83–4.92)§ | <0.0001 |
NE activity nM | 3.39 (3.39–39.66)+ | 95.93 (3.39–179.80)+ | 0.0196 | 3.39 (3.39–3.39)§ | 102.50 (45.85–336.90)§ | <0.0001 |
Neutrophils ×103 cells·mL-1 | 116.50 (16.83–163.04) | 160.92 (39.47–861.49) | 0.1224 | 34.71 (9.62–100.34)§ | 240.45 (129.73–870.74)§ | <0.0001 |
Pseudomonas positive | 1 (3.03)+ | 7 (22.58)+ | 0.0245 | 2 (6.25) | 6 (18.75) | 0.2565 |
Bronchiectasis present | 16 (48.48)+ | 25 (80.65)+ | 0.0096 | 21 (65.63) | 20 (62.50) | 1.0000 |
Bronchiectasis score | 1.00 (0.00–1.75)+ | 2.00 (1.00–10.00)+ | 0.0007 | 1.00 (0.00–2.00)§ | 2.00 (1.00–10.00)§ | 0.0084 |
Data are presented as n, mean±sd, n (%) or median (interquartile range). Values in bold are statistically significant. NE: neutrophil elastase; IL: interleukin. #: bronchoalveolar lavage fluid (BALF) with >104 bacterial CFU·mL-1; ¶: BALF with >200 ng·mL-1 (>6.78 nM); +: statistical significance between no current infection and infected; §: statistical significance between no NE activity and free NE activity.