TABLE 1

Study settings and treatment protocols for the in vivo experiments in rats and mice

StudyBleomycin-induced lung fibrosisSilica-induced lung fibrosis
RatMouseMouse
PosologyOnce daily, oralOnce daily, oralOnce daily, oral
ModelPreventiveTherapeuticPreventiveTherapeuticPreventiveTherapeutic
Dose mg·kg−110, 30, 505030, 6030, 6030, 10030, 100
Study duration days212114213030
Compound administration days0–2110–210–147–210–3010–30, 20–30