TABLE 4

Development of a stepwise approach for risk assessment (primary outcome)

OR95% CIp-valueC-indexSensitivity, % (95% CI)Specificity, % (95% CI)PPV, % (95% CI)NPV, % (95% CI)
sPESI ≥18.381.96–35.850.0040.6792 (75–98)42 (38–46)6 (4–8)99 (97–100)
Additional impact of the age-adjusted hsTnT   cut-off value
 sPESI ≥15.851.35–25.320.0180.7780 (61–91)68 (64–72)9 (6–13)98 (97–100)
 Age-adjusted hsTnT cut-off value#6.591.93–22.440.003
Additional impact of RV dysfunction on   echocardiography
 sPESI ≥15.071.16–22.220.0310.7961 (41–78)84 (81–87)12 (8–20)98 (97–99)
 Age-adjusted hsTnT cut-off value#4.621.31–16.290.017
 RV dysfunction on echocardiography2.330.92–5.960.076
Subanalysis of 403 patients with sPESI ≥1
 Age-adjusted hsTnT cut-off value#5.401.58–18.470.0070.6687 (68–96)45 (40–50)8 (6–13)98 (95–99)
Additional impact of RV dysfunction on   echocardiography
 Age-adjusted hsTnT cut-off value#3.701.04–13.150.0430.7167 (45–83)72 (67–76)12 (8–20)97 (95–99)
 RV dysfunction on echocardiography2.500.93–6.770.071
  • OR: odds ratio; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; sPESI: simplified Pulmonary Embolism Severity Index; hsTnT: high-sensitivity troponin T; RV: right ventricular. #: the age-adjusted hsTnT cut-off value was defined as hsTnT levels ≥14 pg·mL−1 in young (age <75 years) patients and hsTnT levels ≥45 pg·mL−1 in elderly (age ≥75 years) patients.