TABLE 2

Prognostic performance of different high-sensitivity troponin T (hsTnT) cut-off values in all study patients and in elderly (aged ≥75 years) patients with regard to an adverse 30-day outcome

SensitivitySpecificityPPVNPVNRI (95% CI), p-valueOR (95% CI), p-value
All study patients (n=682)
 hsTnT ≥14 pg·mL−1 (established)96 (80–99)41 (37–45)6 (4–9)100 (98–100)16.64 (2.24–123.74), p=0.006
 hsTnT ≥33 pg·mL−1   (patient cohort-specific)80 (61–91)64 (60–67)8 (5–12)99 (97–100)0.07 (-0.09–0.23), p=0.3857.14 (2.64–19.26), p<0.001
 Age-adjusted hsTnT cut-off value#88 (70–96)54 (50–58)7 (5–10)99 (98–100)0.05 (-0.06–0.17), p=0.3698.67 (2.57–29.26), p<0.001
Age ≥75 years (n=248)
 hsTnT ≥14 pg·mL−1 (established)100 (76–100)28 (22–34)7 (4–11)100 (94–100)
 hsTnT ≥45 pg·mL−1 (age-optimised)83 (55–95)64 (58–70)11 (6–19)99 (95–100)0.18 (0.01–0.36), p=0.0419.05 (1.94–42.26), p=0.005
  • Data are presented as % (95% CI), unless otherwise stated. Abbreviations: PPV: positive predictive value; NPV: negative predictive value; NRI: net reclassification improvement; CI: confidence interval; OR: odds ratio; hsTnT: high-sensitivity troponin T. #: the age-adjusted hsTnT cut-off value was defined as hsTnT levels ≥14 pg mL−1 in young (<75 years) patients and hsTnT levels ≥45 pg mL−1 in elderly (≥75 years) patients. : calculation of the odds ratio was not possible since all patients with hsTnT <14 pg mL−1 had a favourable outcome (sensitivity 100%).