Sensitivity | Specificity | PPV | NPV | NRI (95% CI), p-value | OR (95% CI), p-value | |

All study patients (n=682) | ||||||

hsTnT ≥14 pg·mL^{−1} (established) | 96 (80–99) | 41 (37–45) | 6 (4–9) | 100 (98–100) | 16.64 (2.24–123.74), p=0.006 | |

hsTnT ≥33 pg·mL^{−1} (patient cohort-specific) | 80 (61–91) | 64 (60–67) | 8 (5–12) | 99 (97–100) | 0.07 (-0.09–0.23), p=0.385 | 7.14 (2.64–19.26), p<0.001 |

Age-adjusted hsTnT cut-off value^{#} | 88 (70–96) | 54 (50–58) | 7 (5–10) | 99 (98–100) | 0.05 (-0.06–0.17), p=0.369 | 8.67 (2.57–29.26), p<0.001 |

Age ≥75 years (n=248) | ||||||

hsTnT ≥14 pg·mL^{−1} (established) | 100 (76–100) | 28 (22–34) | 7 (4–11) | 100 (94–100) | ^{¶} | |

hsTnT ≥45 pg·mL^{−1} (age-optimised) | 83 (55–95) | 64 (58–70) | 11 (6–19) | 99 (95–100) | 0.18 (0.01–0.36), p=0.041 | 9.05 (1.94–42.26), p=0.005 |

Data are presented as % (95% CI), unless otherwise stated. Abbreviations: PPV: positive predictive value; NPV: negative predictive value; NRI: net reclassification improvement; CI: confidence interval; OR: odds ratio; hsTnT: high-sensitivity troponin T.

^{#}: the age-adjusted hsTnT cut-off value was defined as hsTnT levels ≥14 pg mL^{−1}in young (<75 years) patients and hsTnT levels ≥45 pg mL^{−1}in elderly (≥75 years) patients.^{¶}: calculation of the odds ratio was not possible since all patients with hsTnT <14 pg mL^{−1}had a favourable outcome (sensitivity 100%).