TABLE 1

Baseline characteristics, medical history, and initial presentation of 682 normotensive patients with acute pulmonary embolism

All study patientshsTnT <14 pg·mL−1hsTnT ≥14 pg·mL−1p-value
Patients n682270412
Male sex330 (48.4)132 (48.9)198 (48.1)0.832
Age years70 (54–78)63 (45–74)73 (64–80)<0.001
BMI kg·m−227.0 (23.9–30.4)26.4 (23.3–30.1)27.5 (24.4–30.9)0.014
Risk factors for VTE and comorbidities
 Previous VTE159 (23.3)75 (27.8)84 (20.4)0.027
 Recent# immobilisation/trauma/surgery189 (27.8) (n=681)54 (20.0)135 (32.8) (n=411)<0.001
 Active cancer§115 (16.9) (n=681)38 (14.1)77 (18.7) (n=411)0.112
 Chronic heart failure71 (10.4) (n=681)15 (5.6)56 (13.6) (n=411)0.001
 Chronic pulmonary disease85 (12.5) (n=681)19 (7.0)66 (16.1) (n=411)0.001
 Renal insufficiency207 (30.4)45 (16.7)162 (39.3)<0.001
Clinical presentation
 Symptom duration <24 h212 (45.6) (n=465)70 (38.0) (n=184)142 (50.5) (n=281)0.008
 Chest pain312 (45.7)160 (59.3)152 (36.9)<0.001
 Signs of DVT224 (32.9) (n=681)88 (32.7) (n=269)136 (33.0)0.936
 Dyspnoea558 (81.8)208 (77.0)350 (85.0)0.009
 Syncope119 (17.4)25 (9.3)94 (22.8)<0.001
 Systolic blood pressure mmHg130 (115–146) (n=668)130 (120–150) (n=263)130 (115–144) (n=405)0.039
  Hypotension+50 (7.5)10 (3.8)40 (9.9)0.004
 Heart rate beats·min-190 (80–107) (n=674)86 (75–98) (n=265)95 (83–110) (n=409)<0.001
  Tachycardia247 (36.6)62 (23.4)185 (45.2)<0.001
 RV dysfunction on echocardiography219 (37.2) (n=588)40 (17.7) (n=226)179 (49.4) (n=362)<0.001
 sPESI ≥1403 (59.1)101 (37.4)302 (73.3)<0.001
  • Data are presented as n (%) or median (interquartile range), unless otherwise stated. Patients were stratified according the high-sensitivity troponin T (hsTnT) cut-off value of 14 pg·mL−1. BMI: body mass index; VTE: venous thromboembolism; DVT: deep vein thrombosis; RV: right ventricular; sPESI: simplified pulmonary embolism severity index. #: within the previous 4 weeks; §: defined as active malignancy, anti-tumour therapy within the last 6 months, or metastatic state; +: defined as systolic blood pressure between 90 and 100 mmHg on admission.