| Univariate | Multivariate | |
| Sex | ||
| Male | Ref. | Ref. |
| Female | 1.35 (1.12–1.61) | 1.28 (1.00–1.63) |
| Genotype | ||
| Other | Ref. | |
| Homozygous ΔF508 | 1.54 (1.08–2.21) | |
| Heterozygous ΔF508 | 1.20 (0.84–1.73) | |
| Missing | 3.01 (1.89–4.81) | |
| Pancreatic insufficiency | ||
| Sufficient | Ref. | Ref. |
| Insufficient | 3.18 (2.19–4.61) | 2.19 (1.15–4.17) |
| Age at diagnosis | ||
| <2 years | Ref. | Ref. |
| 2–18 years | 0.62 (0.50–0.77) | 0.79 (0.59–1.06) |
| >18 years | 0.30 (0.20–0.44) | 0.55 (0.28–1.11) |
| Longest time in a region | ||
| Quebec | Ref. | |
| East | 1.53 (1.13–2.09) | |
| Ontario | 1.01 (0.81–1.28) | |
| West | 1.27 (1.00–1.61) | |
| Exacerbations per year | ||
| 0 | Ref. | Ref. |
| 1–2 | 6.17 (3.69–10.31) | 2.98 (2.14–4.15) |
| ≥3 | 11.12 (5.58–21.78) | 4.53 (3.19–6.43) |
| CF-related diabetes | 2.26 (1.36–3.78) | |
| Microbiology# | ||
| Burkholderia cepacia complex | 2.51 (1.40–4.50) | 1.89 (1.44–2.49) |
| Staphylococcus aureus | 0.32 (0.19–0.53) | |
| Pseudomonas aeruginosa | 2.05 (0.98–4.27) | |
| Stenotrophomonas maltophilia | 1.17 (0.73–1.86) | 0.75 (0.58–0.97) |
| MRSA | 0.70 (0.25–1.94) | |
| BMI categories | ||
| Adequate weight | Ref. | Ref. |
| Overweight | 0.22 (0.06–0.80) | 0.80 (0.47–1.35) |
| Underweight | 12.44 (6.26–24.75) | 2.12 (1.60–2.82) |
| FEV1% predicted | 0.91 (0.89–0.93) | 0.95 (0.94–0.96) |
| Birth year | 0.96 (0.93–0.99) |
Data are presented as hazard ratio (95% CI). MRSA: methicillin-resistant S. aureus; BMI: body mass index; FEV1: forced expiratory volume in 1 s. #: reference group for each bacterium was individuals who were culture negative for that bacterium.