TABLE 5 Univariate and multivariate analyses of factors associated with mortality
FactorUnivariate analysisMultivariate analysis
HR (95%CI)p-valueHR (95%CI)p-value
Demographic features
 Age ⩾65 years1.36 (0.97–1.91)0.08
 Male sex1.28 (0.87–1.89)0.21
 ECOG-PS >22.40 (1.63–3.55)<10−42.37 (1.56–3.60)<10−4
 Modified CCI ⩾01.21 (0.85–1.72)0.30
Cancer history
 Metastasis at inclusion1.88 (1.11–3.18)0.02
 Progression1.49 (1.04–2.14)0.03
 Cancer diagnosis >5 months earlier1.04 (0.74–1.45)0.82
Organ failure
 Neurological1.67 (1.17–2.37)4×10−31.67 (1.12–2.48)0.01
 Respiratory1.43 (1.02–2.01)0.042.35 (1.60–3.46)<10−4
 Cardiovascular0.82 (0.56–1.22)0.33
ICU refusal from patient/relatives1.66 (1.16–2.38)4×10−31.67 (1.14–2.44)8×10−3
Referred by pulmonologist1.61 (1.13–2.30)8×10−3
ICU admission0.61 (0.41–0.91)0.02
  • HR: hazard ratio; ECOG-PS: Eastern Cooperative Oncology Group Performance Status; CCI: Charlson Comorbidity Index [19]; ICU: intensive care unit.