| Factor | Univariate analysis | Multivariate analysis | ||
| HR (95%CI) | p-value | HR (95%CI) | p-value | |
| Demographic features | ||||
| Age ⩾65 years | 1.36 (0.97–1.91) | 0.08 | ||
| Male sex | 1.28 (0.87–1.89) | 0.21 | ||
| ECOG-PS >2 | 2.40 (1.63–3.55) | <10−4 | 2.37 (1.56–3.60) | <10−4 |
| Modified CCI ⩾0 | 1.21 (0.85–1.72) | 0.30 | ||
| Cancer history | ||||
| Metastasis at inclusion | 1.88 (1.11–3.18) | 0.02 | ||
| Progression | 1.49 (1.04–2.14) | 0.03 | ||
| Cancer diagnosis >5 months earlier | 1.04 (0.74–1.45) | 0.82 | ||
| Organ failure | ||||
| Neurological | 1.67 (1.17–2.37) | 4×10−3 | 1.67 (1.12–2.48) | 0.01 |
| Respiratory | 1.43 (1.02–2.01) | 0.04 | 2.35 (1.60–3.46) | <10−4 |
| Cardiovascular | 0.82 (0.56–1.22) | 0.33 | ||
| ICU refusal from patient/relatives | 1.66 (1.16–2.38) | 4×10−3 | 1.67 (1.14–2.44) | 8×10−3 |
| Referred by pulmonologist | 1.61 (1.13–2.30) | 8×10−3 | ||
| ICU admission | 0.61 (0.41–0.91) | 0.02 | ||
HR: hazard ratio; ECOG-PS: Eastern Cooperative Oncology Group Performance Status; CCI: Charlson Comorbidity Index [19]; ICU: intensive care unit.