Model 1¶ | Model 2+ | |
Sex | ||
Male | 1 | 1 |
Female | 0.66 (0.50–0.87)* | 0.72 (0.55–0.95)* |
Age at baseline years | 1.10 (1.08–1.12)*** | 1.10 (1.09–1.12)*** |
BMI | ||
Normal 18.5–25 kg·m−2 | 1 | 1 |
Underweight <18.5 kg·m−2 | 2.29 (1.29–4.06)* | 2.27 (1.27–4.07)* |
Overweight 25–30 kg·m−2 | 0.71 (0.54–0.93)* | 0.79 (0.61–1.03) |
Obese ⩾30 kg·m−2 | 1.09 (0.61–1.96) | 1.04 (0.56–1.93) |
Education for >12 years | 0.76 (0.59–0.98)* | 0.80 (0.62–1.03) |
Smoking status | ||
Never-smoker | 1 | 1 |
Former smoker | 0.99 (0.66–1.48) | 1.01 (0.67–1.52) |
Current smoker | 1.27 (0.83–1.92) | 1.29 (0.86–1.94) |
Pack-years | 1.01 (1.00–1.02)*** | 1.01 (1.00–1.01)* |
AL/asthma groups | ||
AL+/asthma- | 1 | 1 |
AL+/asthma+ | 1.58 (1.17–2.12)*** | 1.27 (0.94–1.73) |
FEV1 % predicted at baseline | 0.98 (0.98–0.99)*** |
Data are presented as hazard ratio (95% confidence interval). BMI: body mass index; FEV1: forced expiratory volume in 1 s. #: defined as FEV1/forced vital capacity <70%; ¶: included sex, age, BMI, education, smoking status, pack-years and asthma; +: further adjusted for FEV1% predicted. *: p<0.05; ***: p<0.001.