TABLE 3

Proportion of rates of functional decline in lung function in 73 patients with tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis (LAM) and 319 patients with sporadic LAM#

TSC–LAMSporadic LAM
FEV1DLCOFEV1DLCO
Patients n7373319317
Decline in % predicted
 >10%1 (1.3)4 (5.4)11 (3.4)14 (4.3)
 8–10%3 (4.1)2 (2.7)9 (2.8)10 (3.1)
 6–8%5 (6.8)8 (10.9)19 (5.9)12 (3.7)
 4–6%2 (2.7)4 (5.4)32 (10.0)38 (11.9)
 2–4%13 (17.8)15 (20.5)87 (27.2)84 (26.3)
 0–2%31 (42.4)27 (36.9)95 (29.7)90 (28.2)