Table 3– Association of imputed classical human leukocyte antigen (HLA) class II alleles, rs9273349, and adult-onset asthma in the industrial cohorts of agricultural workers and bakery workers, all subjects ever exposed to occupational high molecular weight (HMW) allergens (industrial cohorts, ESE and B58C) and unexposed subjects

HLA-II allele	AF^#	Industrial HMW allergen exposed only^¶	All HMW allergen exposed⁺	HMW allergen unexposed^§	p-value
					Joint test	Interaction
**DRB101:01***	9.4	0.96 (0.70–1.31)	0.90 (0.71–1.15)	0.83 (0.66–1.04)	0.21	0.62
**DRB103:01***	13.0	1.30 (1.01–1.68)	1.18 (0.97–1.43)	1.11 (0.91–1.36)	0.12	0.68
**DRB104:01***	10.0	0.93 (0.68–1.27)	1.01 (0.80–1.27)	1.10 (0.87–1.38)	0.70	0.61
**DRB107:01***	12.8	0.96 (0.70–1.32)	1.04 (0.84–1.29)	1.01 (0.83–1.23)	0.90	0.84
**DRB115:01***	13.1	0.73 (0.57–0.94)	0.78 (0.65–0.95)	0.88 (0.72–1.07)	0.03	0.43
**DQA101:01***	14.9	1.08 (0.83–1.42)	1.03 (0.84–1.26)	0.88 (0.73–1.06)	0.42	0.27
**DQA101:02***	19.1	0.77 (0.62–0.95)	0.83 (0.71–0.99)	0.90 (0.76–1.06)	0.06	0.53
**DQA101:03***	6.9	1.20 (0.84–1.73)	0.99 (0.75–1.31)	0.83 (0.64–1.07)	0.38	0.35
**DQA102:01***	12.9	0.98 (0.71–1.34)	1.05 (0.85–1.30)	1.01 (0.83–1.23)	0.89	0.79
**DQA103:01***	18.4	0.87 (0.68–1.12)	0.96 (0.80–1.15)	1.11 (0.93–1.32)	0.44	0.26
**DQA105:01***	25.1	1.31 (1.06–1.62)	1.17 (1.01–1.37)	1.16 (1.00–1.34)	0.01	0.91
**DQB102:01***	18.3	1.14 (0.91–1.43)	1.12 (0.95–1.32)	1.05 (0.89–1.24)	0.33	0.58
**DQB103:01***	18.4	1.06 (0.82–1.36)	1.06 (0.89–1.27)	1.14 (0.97–1.33)	0.21	0.59
**DQB103:02***	10.7	0.86 (0.63–1.17)	1.00 (0.80–1.25)	1.04 (0.85–1.29)	0.90	0.79
**DQB105:01***	12.1	1.03 (0.76–1.39)	1.00 (0.80–1.25)	0.86 (0.70–1.06)	0.38	0.32
**DQB106:02***	12.6	0.70 (0.54–0.91)	0.78 (0.64–0.95)	0.89 (0.73–1.09)	0.03	0.37
**DQB106:03***	6.4	1.19 (0.82–1.73)	1.00 (0.75–1.33)	0.81 (0.62–1.06)	0.33	0.29
**DPA101:03***	18.7	1.08 (0.84–1.38)	1.00 (0.83–1.20)	0.95 (0.78–1.15)	0.88	0.69
**DPA102:01***	14.8	1.04 (0.79–1.37)	1.05 (0.86–1.28)	0.92 (0.75–1.12)	0.64	0.35
**DPB102:01***	13.3	1.11 (0.84–1.46)	1.07 (0.87–1.30)	1.25 (1.05–1.50)	0.03	0.24
**DPB103:01***	10.4	1.02 (0.76–1.38)	1.04 (0.84–1.30)	0.67 (0.53–0.86)	0.007	0.009
**DPB104:01***	42.4	0.84 (0.69–1.01)	0.91 (0.79–1.05)	1.03 (0.90–1.18)	0.42	0.22
**DPB104:02***	11.2	1.37 (1.02–1.83)	1.15 (0.93–1.42)	1.05 (0.84–1.30)	0.38	0.55
rs9273349 T	41.4	0.89 (0.74–1.07)	0.86 (0.74–0.99)	0.82 (0.71–0.95)	0.005	0.69

Data are presented as OR (95% CI) unless otherwise stated. AF: allele frequency. ^#: weighted average in industrial cohorts, ESE and B58C; ^¶: n = 946; ⁺: n = 2629; ^§: n = 3396. Bold face indicates p<0.05.