Table 2– Top 20 single nucleotide polymorphisms (SNPs) resulting from the identification from the first meta-analysis (meta 1) and the first replication phase (meta 2)
CHRBpSNPLocusA1Meta 1Meta 2Meta 1+2 p-valueMeta 3Meta 4Meta 5Meta 6Meta 7Meta 8Meta 9Overall
p-valueORp-valueORp-valueORp-valueORp-valueORp-valueORp-valueORp-valueORp-valueORp-value#p-value
215820130rs2112101DDX1T1.32×10−41.165.42×10−31.143.01×10−60.441.040.540.950.381.080.341.110.891.020.451.040.321.090.682.90×10−5
215822156rs6728667DDX1G1.64×10−41.162.67×10−31.151.68×10−60.311.060.370.920.341.090.241.140.721.050.601.020.371.080.531.32×10−5
215822185rs6728750DDX1G1.01×10−41.164.57×10−31.141.99×10−60.361.050.490.940.411.080.231.140.741.040.571.030.071.160.361.10×10−5
215823917rs2544534DDX1T3.14×10−51.181.78×10−31.162.56×10−70.421.040.470.940.421.070.261.130.721.050.401.040.221.110.522.23×10−6
215827908rs1477253DDX1T7.28×10−61.192.52×10−31.151.11×10−70.431.040.610.960.441.070.261.130.771.040.351.040.311.090.611.18×10−6
215830470rs2693008DDX1G1.78×10−51.192.26×10−31.152.06×10−70.401.050.850.980.361.080.141.170.681.050.381.040.691.030.642.23×10−6
215837774rs2544523DDX1T2.39×10−51.181.74×10−31.161.98×10−70.221.070.671.040.541.060.051.230.551.080.131.070.951.010.301.04×10−6
215839739rs2693019DDX1T2.85×10−51.182.04×10−31.162.74×10−70.221.070.641.040.531.060.051.230.551.080.141.070.911.010.291.36×10−6
215840892rs1363058DDX1C1.28×10−41.161.25×10−21.127.66×10−60.251.060.971.000.531.060.011.320.201.180.221.060.910.990.141.60×10−5
215843619rs2544527DDX1T5.07×10−51.181.23×10−21.133.54×10−60.191.070.790.980.261.110.181.160.631.070.181.060.571.050.361.85×10−5
5115623770rs10036292COMMD10G4.04×10−40.784.27×10−30.756.12×10−60.261.120.410.880.821.030.681.080.830.952.47×10−41.320.600.930.054.99×10−6
5115624947rs10043228COMMD10T3.43×10−40.783.58×10−30.754.41×10−60.291.110.400.870.841.030.661.080.820.952.55×10−41.320.600.930.053.84×10−6
5115633819rs254149COMMD10G9.76×10−50.822.81×10−30.831.13×10−60.251.090.240.880.611.050.651.060.691.070.491.040.590.950.711.20×10−5
5116557808rs7718941RP11-535A15.1C7.32×10−51.302.09×10−20.749.12×10−60.431.130.090.820.681.050.080.760.610.920.880.990.260.880.293.69×10−5
1346725490rs7985155GNG5P5G8.38×10−71.601.81×10−21.242.55×10−70.610.930.310.870.330.860.820.960.880.970.450.940.400.880.793.31×10−6
1346728991rs4391953GNG5P5C8.78×10−71.603.18×10−21.225.88×10−70.920.990.301.150.340.860.830.960.830.950.490.950.440.890.867.80×10−6
1346737339rs17069785GNG5P5G3.20×10−51.421.80×10−21.203.97×10−60.120.870.300.880.100.780.830.960.971.010.180.910.760.960.341.95×10−5
1346738025rs17069787GNG5P5A1.58×10−61.587.51×10−31.271.25×10−70.981.000.231.180.420.880.800.950.780.940.470.950.430.890.841.79×10−6
1346739001rs7994542GNG5P5T3.29×10−51.312.06×10−31.223.13×10−70.961.000.960.990.180.840.530.910.941.010.030.870.580.940.532.77×10−6
1346741378rs9534578GNG5P5A6.17×10−71.621.81×10−31.299.96×10−90.640.960.381.130.430.880.780.950.890.970.460.940.320.870.831.62×10−7
  • CHR: chromosome; Bp: base pair; SNP: single nucleotide polymorphism; A1: minor allele and the risk allele; Meta: meta-analysis; T: thymine; G: guanine; C: cytosine; A: adenine #: replication p-value.