Table 1– Characteristics of the identification and replication cohorts
StudyPhenotypeSubjectsAge yearsSex maleCurrent smokerNever smokerEx-smokerPack-years median (IQR)#
DAGAsthma92034±16430 (47)147 (16.0)544 (59.1)226 (24.6)7.9 (2.1–17.3)
Controls277755.4±9.9991 (36)396 (14)1305 (47)1076 (39)1.95 (0–11.6)
NELSONCOPD103063.3±5.61030 (100)410 (39.8)0 (0)620 (60.2)38.7 (29.7–49.5)
Controls844+964+59.1±5964 (100)621 (64. 4)0 (0)343 (35.6)34.2 (27.9–46.2)
LifeLines 1Asthma53444.8±9.7214 (40)106 (19.9)293 (54.9)135 (25.3)10.8 (4.9–20.5)
Controls256843±9.41102 (42.9)266 (10.4)2010 (78.8)276 (10.8)12.75 (5.5–20.4)
COPD71154±10.6369 (52)363 (51.1)0 (0)348 (48.9)16.8 (8.5–26.7)
Controls185443.2±8.6807 (43.5)805 (43.4)0 (0)1049 (56.6)9 (4–15)
LifeLines 2Asthma31746.7±11.2120 (37.9)41 (12.9)171 (53.9)105 (33.1)7.4 (3–15.5)
Controls236348.5±11.6885 (37.5)165 (7.2)1922 (83.3)220 (9.5)12 (5–20.5)
COPD60156.7±10.8282 (46.9)231 (38.4)0 (0)370 (61.6)15.2 (7–25.2)
Controls186849.6±10.9784 (42.0)601 (32.2)0 (0)1267 (67.8)8.6 (4–16)
SAPALDIA 2Asthma46149.0±11.8212 (46.0)95 (20.6)215 (46.6)151 (32.8)16.3 (4.9–32.9)
Controls52251.4±11.1244 (46.7)95 (18.2)252 (48.3)175 (33.5)13.1 (5.1–25.5)
COPD11858.3±10.067 (56.8)44 (37.3)49 (41.5)25 (21.2)37.0 (15.4–52.7)
Controls13451.4±10.460 (44.8)30 (22.4)68 (50.8)36 (26.9)14.8 (3.9–27.0)
RS-IAsthma12665.8±7.833 (26.2)24 (19)50 (40)51 (41)15.4 (4.5–37.4)
Controls424169.8±9.21499 (35.3)782 (18)1854 (44)1605 (38)20 (7.5–37.5)
COPD22979.8±4.9126 (55)51 (22)36 (16)142 (62)26 (9.8–45)
Controls78179.1±4.5306 (39)49 (6)299 (38)433 (55)16.8 (5.7–36.0)
RS-IIAsthma5862.9±6.815 (26)7 (12)23 (40)28 (48)21.6 (6–43.8)
Controls158464.7±8.0712 (45)249 (16)526 (33)809 (51)14 (3.6–31)
COPD18672.8±5.1108 (58)48 (26)28 (15)110 (59)31.7 (16.4–46.0)
Controls78372.1±4.9327 (42)52 (7)317 (41)415 (53)13.9 (3.7–28.0)
RS-IIIAsthma7154.7±4.520 (28)6 (9)27 (38)38 (54)15.5 (1.2–25.7)
Controls171455.8±5.6764 (45)356 (21)574 (34)784 (46)13.8 (4.0–29.0)
COPD7956.9±5.040 (51)32 (41)19 (24)28 (35)28.9 (16.2–44.7)
Controls82456.5±5.5353 (43)137 (17)288 (35)399 (48)12.5 (3.8–26.6)
ARICAsthma45354.3±5.8226 (50)107 (23.62)181 (39.96)165 (36.42)29.6 (14.1–45.0)
Controls920354.8±5.74318 (47)2268 (24.64)3691 (40.11)3239 (35.20)26.0 (12–40)
COPD91555.6±5.57506 (55)522 (57.1)93 (10.2)300 (32.8)39 (29–54)
Controls661054.1±5.673042 (46)1120 (16.9)3096 (46.8)2394 (36.2)20.3 (9–34)
MESAAsthma26761.1±9.6119 (45)29 (11)112 (58)124 (47)20 (6–41.3)
Controls238163.0±10.21149 (48)263 (11)1061 (55)1053 (44)19 (6.6–37.8)
COPD10467.1±8.951 (49)19 (18)15 (14)70 (67)37 (22–64)
Controls97966.0±10.0467 (48)55 (6)446 (46)478 (49)17.3 (7–36)
  • Data are presented as mean±sd or n (%) unless otherwise stated. IQR: interquartile range; DAG: the Dutch Asthma Genome-wide association studies: NELSON: The Dutch–Belgian Randomised Lung Cancer Screening Trial; SAPALDIA: Swiss Cohort Study on Air pollution and Lung Diseases in Adults; ARIC: Atherosclerosis Risk in Communities Study; MESA: Multi-Ethnic Study of Atherosclerosis. #: calculated in ever smokers; : blood bank controls, no demographic data; +: characteristics in this line for n=964.