ParameterGroup 1 (bosentan 125 mg)Group 1 (bosentan 125 mg)Group 1 (bosentan 125 mg)Group 2 (bosentan 250 mg)Group 2 (bosentan 250 mg)Group 2 (bosentan 250 mg)
 BaselineWk3Wk12BaselineWk3Wk12
CD 19+10.3±2.89.5±3.1#*10.9±3.1#7.8±4.46.4±1.6*7.7±2.5*
CD3+HLA-DR+5.5 (2.2-7.5)4.0 (2.5-9.0)2.4 (1.8-4.3)#7.3 (5.2-9.6)6.2 (5.6-9.2)5.9 (4.6-8.8)*
CD3-HLA-DR+11.2±2.410.8±2.511.9±2.7#*9.0±4.28.6±4.88.6±1.9*
CD3+CD95+37.2±12.7#29.9±18.9#33.5±16.547.5±9.346.4±13.632.9±18.6
  • * p<0,05 vs baseline, # p<0,05 group 1 vs group 2